Design and delivery of camplatin to overcome cisplatin drug resistance

Design and delivery of camplatin to overcome cisplatin drug resistance

Camplatin, a prodrug formed via coining camphoric anhydride and cisplatin, was delivered in biodegradable nanoparticles. This camphoric acid and cisplatin co-delivery system exhibited enhanced anticancer activity compared to cisplatin and has successfully overcome cisplatin drug resistance.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-01, Vol.3 (2), p.176-179
Hauptverfasser: Qi, Ruogu, Xiao, Haihua, Wu, Suhong, Li, Yuxin, Zhang, Yu, Jing, Xiabin
Format: Artikel
Sprache:eng
Schlagworte:
Anhydrides
Anticancer properties
Biodegradability
Biology
Chemical compounds
Design engineering
Drugs
Nanoparticles
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Beschreibung
Zusammenfassung:Camplatin, a prodrug formed via coining camphoric anhydride and cisplatin, was delivered in biodegradable nanoparticles. This camphoric acid and cisplatin co-delivery system exhibited enhanced anticancer activity compared to cisplatin and has successfully overcome cisplatin drug resistance.
ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb01146e