Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells

A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg2+ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhib...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-07, Vol.4 (28), p.4934-4940
Hauptverfasser:	Jha, Ajay Kumar, Umar, Shahida, Arya, Rakesh Kumar, Datta, Dipak, Goel, Atul
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Charge transfer Contamination Fluorescence Imaging Ion probes Materials selection Mercury (metal)
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg2+ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhibits high selectivity and sensitivity up to 1.14 ppb. PYJO4 coated test strips can be used to detect mercury ions in contaminated water.
ISSN:	2050-750X 2050-7518
DOI:	10.1039/c6tb01413e