Direct ratiometric detection of nitric oxide with Cu(ii)-based fluorescent probes

Direct ratiometric detection of nitric oxide with Cu(ii)-based fluorescent probes

We report the first Cu(ii)-based fluorescent sensors for ratiometric detection of nitric oxide. The two probes operate by energy transfer between hydroxycoumarin and fluorescein chromophores, contain polyproline or piperazine as rigid spacers, and elicit a rapid and selective ratiometric response up...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-12, Vol.5 (45), p.8929-8933
Hauptverfasser: Loas, A, Lippard, S J
Format: Artikel
Sprache:eng
Schlagworte:
Chromophores
Copper
Energy transfer
Fluorescein
Fluorescent indicators
Nitric oxide
Piperazine
Polyproline
Probes
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Zusammenfassung:We report the first Cu(ii)-based fluorescent sensors for ratiometric detection of nitric oxide. The two probes operate by energy transfer between hydroxycoumarin and fluorescein chromophores, contain polyproline or piperazine as rigid spacers, and elicit a rapid and selective ratiometric response upon direct reaction with nitric oxide.
ISSN:2050-750X
2050-7518
DOI:10.1039/c7tb02666h