Successful percutaneous treatment of bone tumors using microwave ablation in combination with Zoledronic acid infused PMMA cementoplasty

•ZA is a novel, potentially effective therapeutic agent in the treatment of bone tumors.•ZA is a bisphosphonate, which exerts its effect by inducing osteoclast apoptosis.•ZA, ablation and PMMA may be percutaneously administered to treat bone tumors. Whilst surgical resection is traditionally used for the successful eradication of locally aggressive osseous tumors, it is often hazardous or unachievable, particularly in complex anatomic sites, such as the pelvis and spine. The authors present the use of microwave ablation in combination with Zoledronic acid (ZA) administration, alone and with the use of ZA-loaded polymethyl methacrylate (PMMA) to percutaneously treat unresectable bone tumors in 4 patients with giant cell tumors (GCT), multiple myeloma (MM) and breast cancer metastasis.