Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostabi...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-07, Vol.3 (25), p.4993-4996
Hauptverfasser: Zhao, Yueyue, Yu, Chris Y Y, Kwok, Ryan T K, Chen, Yilong, Chen, Sijie, Lam, Jacky W Y, Tang, Ben Zhong
Format: Artikel
Sprache:eng
Schlagworte:
Assaying
Biology
Deoxyribonucleic acid
Derivatives
Dyes
Fluorescence
Medicine
Synthesis
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Beschreibung
Zusammenfassung:Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb00458f