COVID-19 and the Heart

Infection with the severe acute respiratory syndrome novel coronavirus produces a clinical syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers. Here, w...

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Veröffentlicht in:	Circulation research 2020-05, Vol.126 (10), p.1443-1455
Hauptverfasser:	Akhmerov, Akbarshakh, Marbán, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Betacoronavirus Biomarkers Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Cell- and Tissue-Based Therapy Coronavirus Infections - complications Coronavirus Infections - drug therapy Coronavirus Infections - physiopathology Coronavirus Infections - therapy Humans Inflammation Mice Pandemics Peptidyl-Dipeptidase A Pneumonia, Viral - complications Pneumonia, Viral - physiopathology Pneumonia, Viral - therapy
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Beschreibung
Zusammenfassung:	Infection with the severe acute respiratory syndrome novel coronavirus produces a clinical syndrome known as 2019 novel coronavirus disease (COVID-19). When severe, COVID-19 is a systemic illness characterized by hyperinflammation, cytokine storm, and elevations of cardiac injury biomarkers. Here, we review what is known about the pathophysiology of COVID-19, its cardiovascular manifestations, and emerging therapeutic prospects. In this rapidly moving field, this review was comprehensive as of April 3, 2020.
ISSN:	0009-7330 1524-4571
DOI:	10.1161/CIRCRESAHA.120.317055