Regional neurodegeneration correlates with sleep–wake dysfunction after stroke

Regional neurodegeneration correlates with sleep–wake dysfunction after stroke

Abstract Sleep–wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of poststroke sleep dysfunction is unclear. It is not known whether poststroke sleep pathology is due to focal infarction to sleep–wake hubs or to accelerated poststroke neurodegeneration in subcor...

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Veröffentlicht in:Sleep (New York, N.Y.) N.Y.), 2020-09, Vol.43 (9), p.1
Hauptverfasser: Gottlieb, Elie, Egorova, Natalia, Khlif, Mohamed S, Khan, Wasim, Werden, Emilio, Pase, Matthew P, Howard, Mark, Brodtmann, Amy
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Brain - diagnostic imaging
Humans
Magnetic Resonance Imaging
Neurodegeneration
Prospective Studies
Sleep
Stroke
Stroke (Disease)
Stroke - complications
Stroke - diagnostic imaging
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Zusammenfassung:Abstract Sleep–wake disruption is a key modifiable risk factor and sequela of stroke. The pathogenesis of poststroke sleep dysfunction is unclear. It is not known whether poststroke sleep pathology is due to focal infarction to sleep–wake hubs or to accelerated poststroke neurodegeneration in subcortical structures after stroke. We characterize the first prospective poststroke regional brain volumetric and whole-brain, fiber-specific, white matter markers of objectively measured sleep–wake dysfunction. We hypothesized that excessively long sleep (>8 h) duration and poor sleep efficiency (
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsaa054