Leptin affects the inflammatory response after STEMI

Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardial revascularization. Our study, to our best knowledge, is the first showing a direct relationship between leptin serum levels, inflammatory mediators of the ischemia reperfusion damage and effective myocardial reperfusion in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention. Our findings suggest that leptin serum levels are directly associated with the inflammatory response during an acute myocardial infarction and may have a role in risk stratification in this clinical setting. •Inflammation has a central role in the healing process after an ST Elevation Acute Myocardial Infarction.•Leptin has been associated with many functions relevant for cardiovascular health including cytokines production.•Leptin serum levels enhance the inflammatory response during myocardial infarction and affect the effective reperfusion.