Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles
BACKGROUND Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on th...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2020-07, Vol.100 (9), p.3709-3718 |
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| container_title | Journal of the science of food and agriculture |
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| creator | Wu, Xin Gao, Lu‐Min Liu, Yi‐Lin Xie, Chunyan Cai, Lichuang Xu, Kang Zhou, Xi‐Hong |
| description | BACKGROUND
Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets.
RESULTS
Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P |
| doi_str_mv | 10.1002/jsfa.10410 |
| format | Article |
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Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets.
RESULTS
Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P < 0.01); and increased both duodenal and ileal average villus height (P < 0.01) as well as villus height/crypt depth in ileum (P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets (P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum (P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa (P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa (P < 0.05).
CONCLUSIONS
These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in suckling piglets. © 2020 Society of Chemical Industry]]></description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.10410</identifier><identifier>PMID: 32248539</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; Diarrhea ; Diarrhea - metabolism ; Diarrhea - physiopathology ; Diarrhea - prevention & control ; Diarrhea - veterinary ; Diet ; Dietary supplements ; Dietary Supplements - analysis ; Duodenum ; Female ; Gene expression ; Homeostasis ; Ileum ; Ileum - metabolism ; Immune response ; Interleukin-10 - genetics ; Interleukin-10 - metabolism ; intestinal barrier ; Intestinal Mucosa - metabolism ; Intestine ; Jejunum ; Jejunum - metabolism ; Lactation ; Male ; Maternal Inheritance ; Mucosa ; Neonates ; Nucleotides ; Pregnancy ; pregnant sows ; Small intestine ; Suckling behavior ; suckling piglets ; Swine ; Swine Diseases - genetics ; Swine Diseases - metabolism ; Swine Diseases - physiopathology ; Swine Diseases - prevention & control ; TLR4 protein ; Toll-like receptors ; Uridine ; Uridine - metabolism ; Villus ; Weaning</subject><ispartof>Journal of the science of food and agriculture, 2020-07, Vol.100 (9), p.3709-3718</ispartof><rights>2020 Society of Chemical Industry</rights><rights>2020 Society of Chemical Industry.</rights><rights>Copyright © 2020 Society of Chemical Industry</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3980-2d74fa6a52c96cabfd9952ce05bb97927fdce112fb05cc3c0c538885d143d7353</citedby><cites>FETCH-LOGICAL-c3980-2d74fa6a52c96cabfd9952ce05bb97927fdce112fb05cc3c0c538885d143d7353</cites><orcidid>0000-0002-0007-3504 ; 0000-0002-9225-5574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.10410$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.10410$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32248539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xin</creatorcontrib><creatorcontrib>Gao, Lu‐Min</creatorcontrib><creatorcontrib>Liu, Yi‐Lin</creatorcontrib><creatorcontrib>Xie, Chunyan</creatorcontrib><creatorcontrib>Cai, Lichuang</creatorcontrib><creatorcontrib>Xu, Kang</creatorcontrib><creatorcontrib>Zhou, Xi‐Hong</creatorcontrib><title>Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description><![CDATA[BACKGROUND
Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets.
RESULTS
Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P < 0.01); and increased both duodenal and ileal average villus height (P < 0.01) as well as villus height/crypt depth in ileum (P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets (P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum (P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa (P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa (P < 0.05).
CONCLUSIONS
These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in suckling piglets. © 2020 Society of Chemical Industry]]></description><subject>Animals</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Diarrhea</subject><subject>Diarrhea - metabolism</subject><subject>Diarrhea - physiopathology</subject><subject>Diarrhea - prevention & control</subject><subject>Diarrhea - veterinary</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Dietary Supplements - analysis</subject><subject>Duodenum</subject><subject>Female</subject><subject>Gene expression</subject><subject>Homeostasis</subject><subject>Ileum</subject><subject>Ileum - metabolism</subject><subject>Immune response</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - metabolism</subject><subject>intestinal barrier</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine</subject><subject>Jejunum</subject><subject>Jejunum - metabolism</subject><subject>Lactation</subject><subject>Male</subject><subject>Maternal Inheritance</subject><subject>Mucosa</subject><subject>Neonates</subject><subject>Nucleotides</subject><subject>Pregnancy</subject><subject>pregnant sows</subject><subject>Small intestine</subject><subject>Suckling behavior</subject><subject>suckling piglets</subject><subject>Swine</subject><subject>Swine Diseases - genetics</subject><subject>Swine Diseases - metabolism</subject><subject>Swine Diseases - physiopathology</subject><subject>Swine Diseases - prevention & control</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Uridine</subject><subject>Uridine - metabolism</subject><subject>Villus</subject><subject>Weaning</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoreFDQ-ALLFBlQJjO39eVhXlR0UsgHXk2JNbXxIn2LHQfQzemAm3sGDBasaaz-eM5jD2TMArASBfH9JgqCsFPGA7AbopAAQ8ZDsayqISpTxj5ykdAEDrun7MzpSUZVspvWM_P5oVYzAjdx5XE488R-98QJ7ysow4YVjN6ufAI7psMRFnYrxDw32w3mGwSB1f_H7ENfH-SOA-j_Qn7Pl6tw1XTPQiiynbOVHtScFj5CY4bo_r_G3zW-I8-BHTE_ZoMGPCp_f1gn29efPl-l1x--nt--ur28Iq3UIhXVMOpjaVtLq2ph-c1tQjVH2vGy2bwVkUQg49VNYqC7ZSbdtWTpTKNapSF-zlSZeMv2dasZt8sjiOJuCcUydVW5dKtQoIffEPepjzdjSiSiFoHaU3wcsTZeOcUsShW6Kf6KSdgG4LqtuC6n4HRfDze8ncT-j-on-SIUCcgB90lON_pLoPn2-uTqK_AHZmoQs</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Wu, Xin</creator><creator>Gao, Lu‐Min</creator><creator>Liu, Yi‐Lin</creator><creator>Xie, Chunyan</creator><creator>Cai, Lichuang</creator><creator>Xu, Kang</creator><creator>Zhou, Xi‐Hong</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0007-3504</orcidid><orcidid>https://orcid.org/0000-0002-9225-5574</orcidid></search><sort><creationdate>202007</creationdate><title>Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles</title><author>Wu, Xin ; Gao, Lu‐Min ; Liu, Yi‐Lin ; Xie, Chunyan ; Cai, Lichuang ; Xu, Kang ; Zhou, Xi‐Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-2d74fa6a52c96cabfd9952ce05bb97927fdce112fb05cc3c0c538885d143d7353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Diarrhea</topic><topic>Diarrhea - metabolism</topic><topic>Diarrhea - physiopathology</topic><topic>Diarrhea - prevention & control</topic><topic>Diarrhea - veterinary</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Dietary Supplements - analysis</topic><topic>Duodenum</topic><topic>Female</topic><topic>Gene expression</topic><topic>Homeostasis</topic><topic>Ileum</topic><topic>Ileum - metabolism</topic><topic>Immune response</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - metabolism</topic><topic>intestinal barrier</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine</topic><topic>Jejunum</topic><topic>Jejunum - metabolism</topic><topic>Lactation</topic><topic>Male</topic><topic>Maternal Inheritance</topic><topic>Mucosa</topic><topic>Neonates</topic><topic>Nucleotides</topic><topic>Pregnancy</topic><topic>pregnant sows</topic><topic>Small intestine</topic><topic>Suckling behavior</topic><topic>suckling piglets</topic><topic>Swine</topic><topic>Swine Diseases - genetics</topic><topic>Swine Diseases - metabolism</topic><topic>Swine Diseases - physiopathology</topic><topic>Swine Diseases - prevention & control</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Uridine</topic><topic>Uridine - metabolism</topic><topic>Villus</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xin</creatorcontrib><creatorcontrib>Gao, Lu‐Min</creatorcontrib><creatorcontrib>Liu, Yi‐Lin</creatorcontrib><creatorcontrib>Xie, Chunyan</creatorcontrib><creatorcontrib>Cai, Lichuang</creatorcontrib><creatorcontrib>Xu, Kang</creatorcontrib><creatorcontrib>Zhou, Xi‐Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xin</au><au>Gao, Lu‐Min</au><au>Liu, Yi‐Lin</au><au>Xie, Chunyan</au><au>Cai, Lichuang</au><au>Xu, Kang</au><au>Zhou, Xi‐Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2020-07</date><risdate>2020</risdate><volume>100</volume><issue>9</issue><spage>3709</spage><epage>3718</epage><pages>3709-3718</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract><![CDATA[BACKGROUND
Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets.
RESULTS
Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P < 0.01); and increased both duodenal and ileal average villus height (P < 0.01) as well as villus height/crypt depth in ileum (P = 0.017) in neonatal piglets. RT‐qPCR results showed that maternal UR supplementation decreased mRNA expression of claudin‐1 in jejunum and ileum of neonatal piglets (P < 0.05), while significantly increased mRNA expression of claudin‐1 in duodenum and jejunum of suckling piglets. Furthermore, in suckling piglets, maternal dietary UR supplementation increased mRNA expression of IL‐6, IL‐8 and IL‐1β in duodenum, jejunum and ileum (P < 0.05), increased IL‐10 expression in both jejunal and ileal mucosa (P < 0.05) and increased mRNA expression of IKB and TLR4 in ileal mucosa (P < 0.05).
CONCLUSIONS
These results suggest that maternal dietary supplementation with UR contributed to reducing incidence of diarrhea by regulating cytokine secretion and intestinal mucosal barrier function in suckling piglets. © 2020 Society of Chemical Industry]]></abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>32248539</pmid><doi>10.1002/jsfa.10410</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0007-3504</orcidid><orcidid>https://orcid.org/0000-0002-9225-5574</orcidid></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2020-07, Vol.100 (9), p.3709-3718 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cytokines Cytokines - genetics Cytokines - metabolism Diarrhea Diarrhea - metabolism Diarrhea - physiopathology Diarrhea - prevention & control Diarrhea - veterinary Diet Dietary supplements Dietary Supplements - analysis Duodenum Female Gene expression Homeostasis Ileum Ileum - metabolism Immune response Interleukin-10 - genetics Interleukin-10 - metabolism intestinal barrier Intestinal Mucosa - metabolism Intestine Jejunum Jejunum - metabolism Lactation Male Maternal Inheritance Mucosa Neonates Nucleotides Pregnancy pregnant sows Small intestine Suckling behavior suckling piglets Swine Swine Diseases - genetics Swine Diseases - metabolism Swine Diseases - physiopathology Swine Diseases - prevention & control TLR4 protein Toll-like receptors Uridine Uridine - metabolism Villus Weaning |
| title | Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles |
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