Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles

BACKGROUND Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the science of food and agriculture 2020-07, Vol.100 (9), p.3709-3718
Hauptverfasser:	Wu, Xin, Gao, Lu‐Min, Liu, Yi‐Lin, Xie, Chunyan, Cai, Lichuang, Xu, Kang, Zhou, Xi‐Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines Cytokines - genetics Cytokines - metabolism Diarrhea Diarrhea - metabolism Diarrhea - physiopathology Diarrhea - prevention & control Diarrhea - veterinary Diet Dietary supplements Dietary Supplements - analysis Duodenum Female Gene expression Homeostasis Ileum Ileum - metabolism Immune response Interleukin-10 - genetics Interleukin-10 - metabolism intestinal barrier Intestinal Mucosa - metabolism Intestine Jejunum Jejunum - metabolism Lactation Male Maternal Inheritance Mucosa Neonates Nucleotides Pregnancy pregnant sows Small intestine Suckling behavior suckling piglets Swine Swine Diseases - genetics Swine Diseases - metabolism Swine Diseases - physiopathology Swine Diseases - prevention & control TLR4 protein Toll-like receptors Uridine Uridine - metabolism Villus Weaning
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	BACKGROUND Nucleotides play an important role in the regulation of cellular energy and protein homeostasis, which facilitate the repair, recovery and repletion of tissue function. This study tested the effects of maternal uridine (UR) supplementation during late pregnancy and lactation of sows on the immune function of the small intestine in neonatal and suckling piglets. RESULTS Results showed that compared to the control group, maternal dietary UR supplementation significantly decreased incidence of diarrhea in suckling piglets (P
ISSN:	0022-5142 1097-0010
DOI:	10.1002/jsfa.10410