Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation

Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation

Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.

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Veröffentlicht in:Cell stem cell 2020-04, Vol.26 (4), p.473-475
Hauptverfasser: Maybury-Lewis, Sun Y, Webb, Ashley E
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Neural Stem Cells - metabolism
Prisoners
Proteasome Endopeptidase Complex - metabolism
Proteolysis
Vimentin
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Zusammenfassung:Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2020.03.001