Dipleosporalones A and B, Dimeric Azaphilones from a Marine-Derived Pleosporales sp. Fungus

Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2020-04, Vol.83 (4), p.1283-1287
Hauptverfasser:	Cao, Fei, Meng, Zhi-Hui, Wang, Pu, Luo, Du-Qiang, Zhu, Hua-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzopyrans - chemistry Benzopyrans - isolation & purification Benzopyrans - pharmacology Drug Screening Assays, Antitumor Fungi - chemistry Isocoumarins - chemistry Isocoumarins - pharmacology Molecular Structure Pigments, Biological - chemistry Pigments, Biological - isolation & purification Pigments, Biological - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Dipleosporalones A and B (1 and 2), two new [2 + 2] azaphilone dimers, were obtained from a marine-derived Pleosporales sp. fungus. The absolute configurations of 1 and 2 were elucidated by calculations of their ECD spectra. Dipleosporalone A (1) possessed an unprecedented skeleton with an uncommon 6/4/6 ring system. Compounds 1 and 2 showed cytotoxicity about 30–90-fold more potent than that of their monomer pinophilin B.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/acs.jnatprod.0c00132