Effect of antiviral treatment in older patients hospitalized with confirmed influenza
Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza...
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Veröffentlicht in: | Antiviral research 2020-06, Vol.178, p.104785-104785, Article 104785 |
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Sprache: | eng |
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Zusammenfassung: | Seasonal influenza causes significant morbidity and mortality in people aged ≥65 years. Antiviral treatment can reduce complications and disease severity. The objective of this study was to investigate the effect of antiviral treatment in patients aged ≥65 years hospitalized with confirmed influenza in preventing intensive care unit (ICU) admission or death. A retrospective cohort study was carried out in 20 hospitals from seven Spanish regions during 2013–2015 in patients aged ≥65 years. Hospitalized cases of laboratory-confirmed influenza were selected. To assess the association between antiviral treatment and ICU admission or death, the adjusted odds ratios (aOR) and their 95% confidence intervals (CI) were calculated using multivariate logistic regression. We included 715 hospitalized patients, of whom 640 (87.9%) received antiviral treatment, 77 (10.8%) required ICU admission and 66 (9.2%) died. In the 64–74 years age group, receipt of antiviral treatment ≤48 h (aOR 0.20; 95% CI 0.04–0.89), 3–4 days (aOR 0.23; 95% CI 0.05–0.92) and 5–7 days (aOR 0.24; 95% CI 0.03–0.91) after clinical symptom onset was associated with reduced mortality. Receipt of treatment >7 days after symptom onset was not associated with reduced mortality. No association of antiviral treatment with reduced mortality was observed in the >74 years age group or with the prevention of ICU admission in any age group. Antiviral treatment had a protective effect in avoiding death in patients aged 65–74 years hospitalized due to influenza when administered ≤48 h after symptom onset and when no more than 7 days had elapsed.
•Antiviral treatment reduces deaths in hospitalized patients aged 65–74 years.•Antiviral treatment ≤48 hours after symptom onset and when no more than 6 days have elapsed is effective in avoiding deaths.•No association between antiviral treatment and the prevention of mortality was observed in patients aged >74 years.•No association between antiviral treatment and the prevention of ICU admission was observed. |
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ISSN: | 0166-3542 1872-9096 |
DOI: | 10.1016/j.antiviral.2020.104785 |