Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma
The controlling nutritional status (CONUT) score is a nutritional index calculated from serum albumin and total cholesterol levels and lymphocyte counts. Its role in predicting clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) has not been evaluated. In this retrospective study, data from 4...
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| Veröffentlicht in: | Hematological oncology 2020-08, Vol.38 (3), p.309-317 |
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| creator | Nagata, Akihito Kanemasa, Yusuke Sasaki, Yuki Nakamura, Shohei Okuya, Toshihiro Funasaka, Chikako Kageyama, Akihiko Shimoyama, Tatsu Omuro, Yasushi |
| description | The controlling nutritional status (CONUT) score is a nutritional index calculated from serum albumin and total cholesterol levels and lymphocyte counts. Its role in predicting clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) has not been evaluated. In this retrospective study, data from 476 patients with DLBCL were analyzed. The cutoff value of the CONUT score was set as 4. CONUT score significantly stratified the overall survival (OS) and the progression‐free‐survival (PFS) (5‐year OS, 49.0% vs 83.2%, P |
| doi_str_mv | 10.1002/hon.2732 |
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Its role in predicting clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) has not been evaluated. In this retrospective study, data from 476 patients with DLBCL were analyzed. The cutoff value of the CONUT score was set as 4. CONUT score significantly stratified the overall survival (OS) and the progression‐free‐survival (PFS) (5‐year OS, 49.0% vs 83.2%, P < .001; 5‐year PFS, 46.1% vs 73.1%, P < .001) of the patients. Among patients at high‐intermediate or high risk, as per the National Comprehensive Cancer Network International Prognostic Index (NCCN‐IPI), 5‐year OS was lower in patients with high CONUT scores than in those with low CONUT scores (high‐intermediate risk, 51.2% vs 75.5%, P < .001; high risk, 29.9% vs 63.3%, P = .007). Additionally, in patients with high CONUT scores, maintenance of relative dose intensity (RDI) of chemotherapy did not affect the 5‐year OS (RDI > 80% vs RDI ≤ 80%: 59.8% vs 50.9%, P = .73). In the present study, we have demonstrated that the CONUT score is an independent prognostic factor in patients with DLBCL.</description><identifier>ISSN: 0278-0232</identifier><identifier>EISSN: 1099-1069</identifier><identifier>DOI: 10.1002/hon.2732</identifier><identifier>PMID: 32223021</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Inc</publisher><subject>B-cell lymphoma ; Chemotherapy ; Cholesterol ; CONUT score ; diffuse large B‐cell lymphoma ; Lymphocytes ; Lymphoma ; Medical prognosis ; Nutrition assessment ; Nutritional status ; prognostic score ; RDI ; Risk ; Serum albumin ; Survival</subject><ispartof>Hematological oncology, 2020-08, Vol.38 (3), p.309-317</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-b8daf57b9213857d7cbcc1f48db8cfd7f15798a1756cfd03912260c98dd3afd13</citedby><cites>FETCH-LOGICAL-c3492-b8daf57b9213857d7cbcc1f48db8cfd7f15798a1756cfd03912260c98dd3afd13</cites><orcidid>0000-0002-8053-7814</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhon.2732$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhon.2732$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32223021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagata, Akihito</creatorcontrib><creatorcontrib>Kanemasa, Yusuke</creatorcontrib><creatorcontrib>Sasaki, Yuki</creatorcontrib><creatorcontrib>Nakamura, Shohei</creatorcontrib><creatorcontrib>Okuya, Toshihiro</creatorcontrib><creatorcontrib>Funasaka, Chikako</creatorcontrib><creatorcontrib>Kageyama, Akihiko</creatorcontrib><creatorcontrib>Shimoyama, Tatsu</creatorcontrib><creatorcontrib>Omuro, Yasushi</creatorcontrib><title>Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma</title><title>Hematological oncology</title><addtitle>Hematol Oncol</addtitle><description>The controlling nutritional status (CONUT) score is a nutritional index calculated from serum albumin and total cholesterol levels and lymphocyte counts. Its role in predicting clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) has not been evaluated. In this retrospective study, data from 476 patients with DLBCL were analyzed. The cutoff value of the CONUT score was set as 4. CONUT score significantly stratified the overall survival (OS) and the progression‐free‐survival (PFS) (5‐year OS, 49.0% vs 83.2%, P < .001; 5‐year PFS, 46.1% vs 73.1%, P < .001) of the patients. Among patients at high‐intermediate or high risk, as per the National Comprehensive Cancer Network International Prognostic Index (NCCN‐IPI), 5‐year OS was lower in patients with high CONUT scores than in those with low CONUT scores (high‐intermediate risk, 51.2% vs 75.5%, P < .001; high risk, 29.9% vs 63.3%, P = .007). Additionally, in patients with high CONUT scores, maintenance of relative dose intensity (RDI) of chemotherapy did not affect the 5‐year OS (RDI > 80% vs RDI ≤ 80%: 59.8% vs 50.9%, P = .73). In the present study, we have demonstrated that the CONUT score is an independent prognostic factor in patients with DLBCL.</description><subject>B-cell lymphoma</subject><subject>Chemotherapy</subject><subject>Cholesterol</subject><subject>CONUT score</subject><subject>diffuse large B‐cell lymphoma</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Nutrition assessment</subject><subject>Nutritional status</subject><subject>prognostic score</subject><subject>RDI</subject><subject>Risk</subject><subject>Serum albumin</subject><subject>Survival</subject><issn>0278-0232</issn><issn>1099-1069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc-KFDEQh4Mo7rgKPoEEvHjpNal0T5KjDuoKi3vRc5POn5ks6aRN0ixz8xF8Rp_EjLsqCJ6Kor58VOWH0HNKLigh8PqQ4gVwBg_QhhIpO0q28iHaEOCiI8DgDD0p5YaQNiPiMTpjAMAI0A067oKPXquA_bwoXXFyWKdYcwptsMdxrdlXn2IjSlV1LbjolC1OEdeDxUtO-5iKL6eHi6rexlrwra8HbLxza7E4qLy3-O2Pb9-1DQGH47wc0qyeokdOhWKf3ddz9OX9u8-7y-7q-sPH3ZurTrNeQjcJo9zAJwmUiYEbrietqeuFmYR2hjs6cCkU5cO2tYRJCrAlWgpjmHKGsnP06s7bVv262lLH2ZfTJiratJYRmOh7KajkDX35D3qT1txOb1TPBqBiC-SvUOdUSrZuXLKfVT6OlIynOMYWx3iKo6Ev7oXrNFvzB_z9_w3o7oBbH-zxv6Lx8vrTL-FP5yeWPg</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Nagata, Akihito</creator><creator>Kanemasa, Yusuke</creator><creator>Sasaki, Yuki</creator><creator>Nakamura, Shohei</creator><creator>Okuya, Toshihiro</creator><creator>Funasaka, Chikako</creator><creator>Kageyama, Akihiko</creator><creator>Shimoyama, Tatsu</creator><creator>Omuro, Yasushi</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8053-7814</orcidid></search><sort><creationdate>202008</creationdate><title>Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma</title><author>Nagata, Akihito ; Kanemasa, Yusuke ; Sasaki, Yuki ; Nakamura, Shohei ; Okuya, Toshihiro ; Funasaka, Chikako ; Kageyama, Akihiko ; Shimoyama, Tatsu ; Omuro, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-b8daf57b9213857d7cbcc1f48db8cfd7f15798a1756cfd03912260c98dd3afd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>B-cell lymphoma</topic><topic>Chemotherapy</topic><topic>Cholesterol</topic><topic>CONUT score</topic><topic>diffuse large B‐cell lymphoma</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Medical prognosis</topic><topic>Nutrition assessment</topic><topic>Nutritional status</topic><topic>prognostic score</topic><topic>RDI</topic><topic>Risk</topic><topic>Serum albumin</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagata, Akihito</creatorcontrib><creatorcontrib>Kanemasa, Yusuke</creatorcontrib><creatorcontrib>Sasaki, Yuki</creatorcontrib><creatorcontrib>Nakamura, Shohei</creatorcontrib><creatorcontrib>Okuya, Toshihiro</creatorcontrib><creatorcontrib>Funasaka, Chikako</creatorcontrib><creatorcontrib>Kageyama, Akihiko</creatorcontrib><creatorcontrib>Shimoyama, Tatsu</creatorcontrib><creatorcontrib>Omuro, Yasushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hematological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagata, Akihito</au><au>Kanemasa, Yusuke</au><au>Sasaki, Yuki</au><au>Nakamura, Shohei</au><au>Okuya, Toshihiro</au><au>Funasaka, Chikako</au><au>Kageyama, Akihiko</au><au>Shimoyama, Tatsu</au><au>Omuro, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma</atitle><jtitle>Hematological oncology</jtitle><addtitle>Hematol Oncol</addtitle><date>2020-08</date><risdate>2020</risdate><volume>38</volume><issue>3</issue><spage>309</spage><epage>317</epage><pages>309-317</pages><issn>0278-0232</issn><eissn>1099-1069</eissn><abstract>The controlling nutritional status (CONUT) score is a nutritional index calculated from serum albumin and total cholesterol levels and lymphocyte counts. Its role in predicting clinical outcomes of diffuse large B‐cell lymphoma (DLBCL) has not been evaluated. In this retrospective study, data from 476 patients with DLBCL were analyzed. The cutoff value of the CONUT score was set as 4. CONUT score significantly stratified the overall survival (OS) and the progression‐free‐survival (PFS) (5‐year OS, 49.0% vs 83.2%, P < .001; 5‐year PFS, 46.1% vs 73.1%, P < .001) of the patients. Among patients at high‐intermediate or high risk, as per the National Comprehensive Cancer Network International Prognostic Index (NCCN‐IPI), 5‐year OS was lower in patients with high CONUT scores than in those with low CONUT scores (high‐intermediate risk, 51.2% vs 75.5%, P < .001; high risk, 29.9% vs 63.3%, P = .007). Additionally, in patients with high CONUT scores, maintenance of relative dose intensity (RDI) of chemotherapy did not affect the 5‐year OS (RDI > 80% vs RDI ≤ 80%: 59.8% vs 50.9%, P = .73). In the present study, we have demonstrated that the CONUT score is an independent prognostic factor in patients with DLBCL.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Inc</pub><pmid>32223021</pmid><doi>10.1002/hon.2732</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8053-7814</orcidid></addata></record> |
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| subjects | B-cell lymphoma Chemotherapy Cholesterol CONUT score diffuse large B‐cell lymphoma Lymphocytes Lymphoma Medical prognosis Nutrition assessment Nutritional status prognostic score RDI Risk Serum albumin Survival |
| title | Clinical impact of controlling nutritional status score on the prognosis of patients with diffuse large B‐cell lymphoma |
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