Cohesin Is Out for Stalled Replication Fork Restart

Cohesin Is Out for Stalled Replication Fork Restart

Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival following replication stress, uncovering an unexpected link be...

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Veröffentlicht in:Developmental cell 2020-03, Vol.52 (6), p.675-676
Hauptverfasser: Eksi, Sebnem Ece, Saldivar, Joshua C.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Cycle Proteins
Chromatids
Chromosomal Proteins, Non-Histone
Cohesins
DNA
DNA Replication
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Zusammenfassung:Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival following replication stress, uncovering an unexpected link between stress and sister chromatid cohesion loss. Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival following replication stress, uncovering an unexpected link between stress and sister chromatid cohesion loss.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2020.03.001