A20 restricts inflammation via ubiquitin binding

The ubiquitin-editing enzyme A20 has a pivotal role in restricting autoimmune and inflammatory responses. New studies suggest that A20 prevents inflammatory diseases using a non-catalytic mechanism involving ubiquitin binding.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2020-04, Vol.21 (4), p.362-364
1. Verfasser:	Sun, Shao-Cong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/249/2510/2511 631/250/256/2515 631/250/262 Arthritis Arthritis, Psoriatic Biomedical and Life Sciences Biomedicine Cellular signal transduction Chronic illnesses Cytokines Enzymes Genetic aspects Genotype & phenotype Health aspects Humans Immunology Infections Infectious Diseases Inflammation Inflammatory diseases Lymphatic system Lymphocytes Mutation News & Views news-and-views Physiology Protein Binding Senescence Tumor Necrosis Factor alpha-Induced Protein 3 Tumor necrosis factor-TNF Ubiquitin Ubiquitin-proteasome system Ubiquitins Viruses
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Beschreibung
Zusammenfassung:	The ubiquitin-editing enzyme A20 has a pivotal role in restricting autoimmune and inflammatory responses. New studies suggest that A20 prevents inflammatory diseases using a non-catalytic mechanism involving ubiquitin binding.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-020-0632-6