Influence of HLA 1–3-locus mismatch and antithymocyte globulin administration in unrelated bone marrow transplantation

For patients without an HLA-matched donor, an HLA-mismatched unrelated donor (MMUD) has been considered as an alternative donor in allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a nationwide retrospective study to compare the transplant outcomes among 1-, 2-, and 3-locus (all...

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Veröffentlicht in:Annals of hematology 2020-05, Vol.99 (5), p.1099-1110
Hauptverfasser: Kawamura, Koji, Kanda, Junya, Ohashi, Kazuteru, Fukuda, Takahiro, Iwato, Koji, Eto, Tetsuya, Fujiwara, Shin-ichiro, Mori, Takehiko, Fukushima, Kentaro, Ozawa, Yukiyasu, Uchida, Naoyuki, Ashida, Takashi, Ichinohe, Tatsuo, Atsuta, Yoshiko, Kanda, Yoshinobu
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Sprache:eng
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Zusammenfassung:For patients without an HLA-matched donor, an HLA-mismatched unrelated donor (MMUD) has been considered as an alternative donor in allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a nationwide retrospective study to compare the transplant outcomes among 1-, 2-, and 3-locus (allele/antigen) mismatched unrelated donors (1MMUD n  = 2044, 2MMUD n  = 492, and 3MMUD n  = 73) in allo-HCT and to assess the impact of antithymocyte globulin (ATG) in allo-HCT from 1-3MMUD. 2MMUD and 3MMUD were independent significant adverse factors for grade III–IV acute graft-versus-host disease (GVHD) (hazard ratio [HR] 1.72, p  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-020-03995-7