Cryptic and atypical KMT2A‐USP2 and KMT2A‐USP8 rearrangements identified by mate pair sequencing in infant and childhood leukemia

Infant leukemias are a rare group of neoplasms that are clinically and biologically distinct from their pediatric and adult counterparts. Unlike leukemia in older children where survival rates are generally favorable, infants with leukemia have a 5‐year event‐free survival rate of

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Bibliographische Detailangaben
Veröffentlicht in:	Genes chromosomes & cancer 2020-07, Vol.59 (7), p.422-427
Hauptverfasser:	Blackburn, Patrick R., Smadbeck, James B., Znoyko, Iya, Webley, Matthew R., Pitel, Beth A., Vasmatzis, George, Xu, Xinjie, Greipp, Patricia T., Hoppman, Nicole L., Ketterling, Rhett P., Baughn, Linda B., Lindsey, Kathryn G., Schandl, Cynthia A., Wolff, Daynna J., Peterson, Jess F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia B‐lymphoblastic leukemia/lymphoma (B‐ALL/LBL) Central nervous system Childhood Children Chromosome deletion Cytogenetics DNA microarrays Endopeptidases - genetics Endosomal Sorting Complexes Required for Transport - genetics Female Gene deletion Gene Rearrangement Genetic Testing - methods Histone-Lysine N-Methyltransferase - genetics Humans Infant infant leukemia Infants Karyotypes KMT2A Leukemia Leukemogenesis Lymphatic leukemia Male mixed‐phenotype acute leukemia (MPAL) Myeloid-Lymphoid Leukemia Protein - genetics Pediatrics Phenotypes Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prednisone Survival Trisomy Ubiquitin Thiolesterase - genetics USP2 USP8
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Beschreibung
Zusammenfassung:	Infant leukemias are a rare group of neoplasms that are clinically and biologically distinct from their pediatric and adult counterparts. Unlike leukemia in older children where survival rates are generally favorable, infants with leukemia have a 5‐year event‐free survival rate of
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.22842