Mood Disorders are Associated With Increased Risk of BPPV: A National Sample Cohort

Objectives Few studies have reported that mood disorders increase the risk of benign paroxysmal positional vertigo (BPPV). The purpose of our study was to demonstrate whether the incidence of BPPV in those with mood disorders differs from that in a matched control group. Study Design Nationwide cohort observational study. Methods Korean Health Insurance Review and Assessment Service‐National Patient Samples were collected from 2002 to 2013. A 1:4 matched mood disorder group (n = 59,340) and control group (n = 237,720) were selected. The crude and adjusted (cerebral stroke, ischemic heart disease, anxiety disorder, and osteoporosis histories) hazard ratios (HRs) for depression and BPPV were analyzed using a stratified Cox proportional hazard model. The results were stratified by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia in these analyses. Results The incidence of BPPV was significantly higher in the mood disorder group than in the control group (3.2% vs. 2.1%, P