Long-term bone mineral density changes after surgical cure of patients with tumor-induced osteomalacia

Summary This paper reports our personal experience filling the gap regarding changes of bone mineral density after surgical treatment in patient suffering from tumor-induced osteomalacia. Introduction No systematic data are available regarding long-term bone mineral density (BMD) changes after surgical cure of patients with tumor-induced osteomalacia. Methods From October 2001 through April 2018, we studied 10 consecutive patients (mean age ± SD, 45.5 ± 13.8 years; 5 males and 5 females) with tumor-induced osteomalacia. We evaluated BMD when initially presented at our Center and after surgical removal of the tumor. Results Basal BMD and corresponding Z-score values (mean values ± SD) measured by DXA were as follows: L 1 –L 4 = 0.692 ± 0.15 g/cm 2 , Z-score = − 2.80 ± 1.60; femur neck 0.447 ± 0.10 g/cm 2 , Z-score = − 2.66 ± 0.93; total femur = 0.450 ± 0.08 g/cm 2 , Z-score = −3.04 ± 0.85). Furthermore, Trabecular Bone Score (TBS) was evaluated in three patients (basal values, 0.990 ± 0.32). Seven patients were intermittently followed after surgical excision of the tumor while supplemented with cholecalciferol and calcium salts; the remaining three were lost to follow-up. There was a striking increase of BMD values that peaked at 26.7 ± 6.50 months: L 1 –L 4 = 1.289 ± 0.247 g/cm 2 , p