Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity
Background Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear. Objectives To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents wi...
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| Veröffentlicht in: | Pediatric diabetes 2020-06, Vol.21 (4), p.657-663 |
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| creator | Santucci, María P. Muzzio, María L. Peredo, Maria S. Brovarone, Lucrecia Scricciolo, Romina Diez, Cecilia Andrés‐Lacueva, Cristina Kabakian, María L. Meroño, Tomás |
| description | Background
Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear.
Objectives
To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB.
Methods
Cross‐sectional study of 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). Patients with an albumin‐creatinine ratio >3.39 mg/mmol were excluded. GFR was estimated with creatinine‐cystatin C Zappitelli equation. HF and low GFR were defined by a GFR > 135 and |
| doi_str_mv | 10.1111/pedi.13008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2377997638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377997638</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3938-474d319907b26394abf51b5fe4ad87481ff245db9ab73fa021f501a5c2fe924d3</originalsourceid><addsrcrecordid>eNp9kbFOHDEQhq0oKBBCkweILKWJIh3Yay9elxGQBAmJFIlEZ3nXY26Qb32xvTnd--RB8bFAQYGbsWa--f-RfkI-cnbM6ztZg8NjLhjr3pADLrRetFJ2b5__4mafvM_5jjGutJDvyL5oeMe14gfk_zl6DwnGQm0okGzBOGYaPb0NcQVpCjZRj6HME1oLUDs6WpaAidqc44DzaINlSaeEA7UDOoojHZYYXNV-WLAuBshDdcozWrZroJw6tD0UqJ5p7sd_kDaAt8tyEnvIWLYfyJ63IcPRYz0kf75f_D77ubi6_nF59u1qMQgtuoVU0gmuNVN9cyq0tL1ved96kNZ1Snbc-0a2rte2V8Jb1nDfMm7bofGgm7p7SL7MuusU_06Qi1lhvTgEO0KcsmmEUlqrU9FV9PML9C5OaazXmUYyVn1atqO-ztSQYs4JvFknXNm0NZyZXXZml515yK7Cnx4lp34F7hl9CqsCfAY2GGD7ipT5dXF-OYveA2SGp0Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2400245508</pqid></control><display><type>article</type><title>Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Santucci, María P. ; Muzzio, María L. ; Peredo, Maria S. ; Brovarone, Lucrecia ; Scricciolo, Romina ; Diez, Cecilia ; Andrés‐Lacueva, Cristina ; Kabakian, María L. ; Meroño, Tomás</creator><creatorcontrib>Santucci, María P. ; Muzzio, María L. ; Peredo, Maria S. ; Brovarone, Lucrecia ; Scricciolo, Romina ; Diez, Cecilia ; Andrés‐Lacueva, Cristina ; Kabakian, María L. ; Meroño, Tomás</creatorcontrib><description><![CDATA[Background
Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear.
Objectives
To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB.
Methods
Cross‐sectional study of 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). Patients with an albumin‐creatinine ratio >3.39 mg/mmol were excluded. GFR was estimated with creatinine‐cystatin C Zappitelli equation. HF and low GFR were defined by a GFR > 135 and <90 mL/min.1.73 m2, respectively.
Results
HF was higher in children with T1D vs OW/OB (28% vs 10%, P < .005). Children with OW/OB also showed a 10% of low GFR. In patients with T1D, HbA1c (β = .8, P < .001), and systolic blood pressure (β = 11.4, P < .005) were independent predictors of GFR (R2 = .65). In OW/OB, HF cases were almost limited to prepubertal children and low GFR to pubertal ones. GFR in OW/OB was associated with age (β = −2.2, P < .001), male sex (β = −11.6, P < .001), and uric acid (β = −.05, P < .001) in adjusted models (R2 = .33).
Conclusions
GFR alterations were different between youths with T1D and with OW/OB. Higher uric acid, older age, and puberty were related to lower GFR values in OW/OB children. Longitudinal studies will determine if low GFR is consequence of a rapid GFR decline in pediatric patients with OW/OB.]]></description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/pedi.13008</identifier><identifier>PMID: 32181971</identifier><language>eng</language><publisher>Former Munksgaard: John Wiley & Sons A/S</publisher><subject>Adolescents ; Blood pressure ; Body weight ; Children ; Creatinine ; Cystatin C ; Diabetes ; Diabetes mellitus (insulin dependent) ; Glomerular filtration rate ; hyperfiltration ; Kidney diseases ; Obesity ; Overweight ; Puberty ; renal disease ; Teenagers ; Uric acid</subject><ispartof>Pediatric diabetes, 2020-06, Vol.21 (4), p.657-663</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3938-474d319907b26394abf51b5fe4ad87481ff245db9ab73fa021f501a5c2fe924d3</citedby><cites>FETCH-LOGICAL-c3938-474d319907b26394abf51b5fe4ad87481ff245db9ab73fa021f501a5c2fe924d3</cites><orcidid>0000-0002-2673-3494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpedi.13008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpedi.13008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32181971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santucci, María P.</creatorcontrib><creatorcontrib>Muzzio, María L.</creatorcontrib><creatorcontrib>Peredo, Maria S.</creatorcontrib><creatorcontrib>Brovarone, Lucrecia</creatorcontrib><creatorcontrib>Scricciolo, Romina</creatorcontrib><creatorcontrib>Diez, Cecilia</creatorcontrib><creatorcontrib>Andrés‐Lacueva, Cristina</creatorcontrib><creatorcontrib>Kabakian, María L.</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><title>Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description><![CDATA[Background
Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear.
Objectives
To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB.
Methods
Cross‐sectional study of 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). Patients with an albumin‐creatinine ratio >3.39 mg/mmol were excluded. GFR was estimated with creatinine‐cystatin C Zappitelli equation. HF and low GFR were defined by a GFR > 135 and <90 mL/min.1.73 m2, respectively.
Results
HF was higher in children with T1D vs OW/OB (28% vs 10%, P < .005). Children with OW/OB also showed a 10% of low GFR. In patients with T1D, HbA1c (β = .8, P < .001), and systolic blood pressure (β = 11.4, P < .005) were independent predictors of GFR (R2 = .65). In OW/OB, HF cases were almost limited to prepubertal children and low GFR to pubertal ones. GFR in OW/OB was associated with age (β = −2.2, P < .001), male sex (β = −11.6, P < .001), and uric acid (β = −.05, P < .001) in adjusted models (R2 = .33).
Conclusions
GFR alterations were different between youths with T1D and with OW/OB. Higher uric acid, older age, and puberty were related to lower GFR values in OW/OB children. Longitudinal studies will determine if low GFR is consequence of a rapid GFR decline in pediatric patients with OW/OB.]]></description><subject>Adolescents</subject><subject>Blood pressure</subject><subject>Body weight</subject><subject>Children</subject><subject>Creatinine</subject><subject>Cystatin C</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Glomerular filtration rate</subject><subject>hyperfiltration</subject><subject>Kidney diseases</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Puberty</subject><subject>renal disease</subject><subject>Teenagers</subject><subject>Uric acid</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kbFOHDEQhq0oKBBCkweILKWJIh3Yay9elxGQBAmJFIlEZ3nXY26Qb32xvTnd--RB8bFAQYGbsWa--f-RfkI-cnbM6ztZg8NjLhjr3pADLrRetFJ2b5__4mafvM_5jjGutJDvyL5oeMe14gfk_zl6DwnGQm0okGzBOGYaPb0NcQVpCjZRj6HME1oLUDs6WpaAidqc44DzaINlSaeEA7UDOoojHZYYXNV-WLAuBshDdcozWrZroJw6tD0UqJ5p7sd_kDaAt8tyEnvIWLYfyJ63IcPRYz0kf75f_D77ubi6_nF59u1qMQgtuoVU0gmuNVN9cyq0tL1ved96kNZ1Snbc-0a2rte2V8Jb1nDfMm7bofGgm7p7SL7MuusU_06Qi1lhvTgEO0KcsmmEUlqrU9FV9PML9C5OaazXmUYyVn1atqO-ztSQYs4JvFknXNm0NZyZXXZml515yK7Cnx4lp34F7hl9CqsCfAY2GGD7ipT5dXF-OYveA2SGp0Y</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Santucci, María P.</creator><creator>Muzzio, María L.</creator><creator>Peredo, Maria S.</creator><creator>Brovarone, Lucrecia</creator><creator>Scricciolo, Romina</creator><creator>Diez, Cecilia</creator><creator>Andrés‐Lacueva, Cristina</creator><creator>Kabakian, María L.</creator><creator>Meroño, Tomás</creator><general>John Wiley & Sons A/S</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2673-3494</orcidid></search><sort><creationdate>202006</creationdate><title>Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity</title><author>Santucci, María P. ; Muzzio, María L. ; Peredo, Maria S. ; Brovarone, Lucrecia ; Scricciolo, Romina ; Diez, Cecilia ; Andrés‐Lacueva, Cristina ; Kabakian, María L. ; Meroño, Tomás</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-474d319907b26394abf51b5fe4ad87481ff245db9ab73fa021f501a5c2fe924d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescents</topic><topic>Blood pressure</topic><topic>Body weight</topic><topic>Children</topic><topic>Creatinine</topic><topic>Cystatin C</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Glomerular filtration rate</topic><topic>hyperfiltration</topic><topic>Kidney diseases</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Puberty</topic><topic>renal disease</topic><topic>Teenagers</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santucci, María P.</creatorcontrib><creatorcontrib>Muzzio, María L.</creatorcontrib><creatorcontrib>Peredo, Maria S.</creatorcontrib><creatorcontrib>Brovarone, Lucrecia</creatorcontrib><creatorcontrib>Scricciolo, Romina</creatorcontrib><creatorcontrib>Diez, Cecilia</creatorcontrib><creatorcontrib>Andrés‐Lacueva, Cristina</creatorcontrib><creatorcontrib>Kabakian, María L.</creatorcontrib><creatorcontrib>Meroño, Tomás</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santucci, María P.</au><au>Muzzio, María L.</au><au>Peredo, Maria S.</au><au>Brovarone, Lucrecia</au><au>Scricciolo, Romina</au><au>Diez, Cecilia</au><au>Andrés‐Lacueva, Cristina</au><au>Kabakian, María L.</au><au>Meroño, Tomás</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2020-06</date><risdate>2020</risdate><volume>21</volume><issue>4</issue><spage>657</spage><epage>663</epage><pages>657-663</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract><![CDATA[Background
Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear.
Objectives
To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB.
Methods
Cross‐sectional study of 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). Patients with an albumin‐creatinine ratio >3.39 mg/mmol were excluded. GFR was estimated with creatinine‐cystatin C Zappitelli equation. HF and low GFR were defined by a GFR > 135 and <90 mL/min.1.73 m2, respectively.
Results
HF was higher in children with T1D vs OW/OB (28% vs 10%, P < .005). Children with OW/OB also showed a 10% of low GFR. In patients with T1D, HbA1c (β = .8, P < .001), and systolic blood pressure (β = 11.4, P < .005) were independent predictors of GFR (R2 = .65). In OW/OB, HF cases were almost limited to prepubertal children and low GFR to pubertal ones. GFR in OW/OB was associated with age (β = −2.2, P < .001), male sex (β = −11.6, P < .001), and uric acid (β = −.05, P < .001) in adjusted models (R2 = .33).
Conclusions
GFR alterations were different between youths with T1D and with OW/OB. Higher uric acid, older age, and puberty were related to lower GFR values in OW/OB children. Longitudinal studies will determine if low GFR is consequence of a rapid GFR decline in pediatric patients with OW/OB.]]></abstract><cop>Former Munksgaard</cop><pub>John Wiley & Sons A/S</pub><pmid>32181971</pmid><doi>10.1111/pedi.13008</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2673-3494</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1399-543X |
| ispartof | Pediatric diabetes, 2020-06, Vol.21 (4), p.657-663 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescents Blood pressure Body weight Children Creatinine Cystatin C Diabetes Diabetes mellitus (insulin dependent) Glomerular filtration rate hyperfiltration Kidney diseases Obesity Overweight Puberty renal disease Teenagers Uric acid |
| title | Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity |
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