Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity

Background Hyperfiltration (HF) occurs early in diabetes or obesity (OB)‐associated renal disease. Alterations of glomerular filtration rate (GFR) in childhood OB remain unclear. Objectives To compare the prevalence of GFR alterations and its association with uric acid in children and adolescents with type 1 diabetes (T1D) vs overweight (OW)/OB. Methods Cross‐sectional study of 29 youths (aged: 13 ± 2 years) with T1D (disease duration: 7 ± 3 years) and 165 with OW/OB (aged: 11 ± 3 years). Patients with an albumin‐creatinine ratio >3.39 mg/mmol were excluded. GFR was estimated with creatinine‐cystatin C Zappitelli equation. HF and low GFR were defined by a GFR > 135 and