Mitochondrial distress call moves to the cytosol to trigger a response to stress

Mitochondrial distress call moves to the cytosol to trigger a response to stress

Cellular stress can result in dysfunction and disease, and mechanisms exist to combat this. Previously unknown steps have been uncovered in a pathway that signals when mitochondrial organelles are dysfunctional. Cleaved protein is a signal that activates the integrated stress response.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2020-03, Vol.579 (7799), p.348-349
Hauptverfasser: Tremblay, Bradford P., Haynes, Cole M.
Format: Artikel
Sprache:eng
Schlagworte:
631/45
631/80
Chromatin
Cytosol
Genetic transcription
Influence
Mitochondria
Mitochondrial Proteins
News And Views
Physiological aspects
Stress (Physiology)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cellular stress can result in dysfunction and disease, and mechanisms exist to combat this. Previously unknown steps have been uncovered in a pathway that signals when mitochondrial organelles are dysfunctional. Cleaved protein is a signal that activates the integrated stress response.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-020-00552-0