Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer

Purpose DCBLD2 expression dysregulation has been reported in several types of human cancer. As yet, however, the role of DCBLD2 in colorectal cancer (CRC) is not known. Methods CRC tissues were obtained from patients undergoing surgery from February 2009 to May 2014 ( n = 90). Tissue microarray construction and immunohistochemistry were carried out to determine DCBLD2 expression. In vivo studies were performed in 4-week-old BALB/c nude mice. In vitro studies were conducted using CRC-derived HT29 and HCT116 cell lines. Results DCBLD2 expression was found to be significantly increased in CRC tissues compared to adjacent normal tissues ( p