Prediction of response to first-line therapy with ITP by flow cytometric analysis of bone marrow lymphocyte phenotypes

Prediction of response to first-line therapy with ITP by flow cytometric analysis of bone marrow lymphocyte phenotypes

In the present study, we analyzed phenotypes of cells in the lymphocyte region of bone marrow in 68 patients with primary immune thrombocytopenia (ITP) to determine whether cellular phenotype predicts response to first-line therapy (corticosteroids or corticosteroids plus intravenous immunoglobulin)...

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Veröffentlicht in:International journal of hematology 2020-06, Vol.111 (6), p.771-778
Hauptverfasser: Oka, Satoko, Ono, Kazuo, Nohgawa, Masaharu
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
CD19 antigen
CD4 antigen
CD8 antigen
Corticoids
Corticosteroids
Flow cytometry
Hematology
Idiopathic thrombocytopenic purpura
Intravenous administration
Lymphocytes
Lymphocytes B
Medicine
Medicine & Public Health
Oncology
Original Article
Phenotypes
Thrombocytopenia
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Beschreibung
Zusammenfassung:In the present study, we analyzed phenotypes of cells in the lymphocyte region of bone marrow in 68 patients with primary immune thrombocytopenia (ITP) to determine whether cellular phenotype predicts response to first-line therapy (corticosteroids or corticosteroids plus intravenous immunoglobulin). In 52 newly diagnosed ITP patients, an abnormal CD4:CD8 ratio (CD4/CD8 ratio 
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-020-02847-4