Methods of Generation of Induced Pluripotent Stem Cells and Their Application for the Therapy of Central Nervous System Diseases

The use of induced pluripotent stem cells (IPSC) is a promising approach to the therapy of CNS diseases. The undeniable advantage of IPSC technology is the possibility of obtaining practically all types of somatic cells for autologous transplantation bypassing bioethical problems. The review present...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2020-02, Vol.168 (4), p.566-573
Hauptverfasser:	Cherkashova, E. A., Leonov, G. E., Namestnikova, D. D., Solov’eva, A. A., Gubskii, I. L., Bukharova, T. B., Gubskii, L. V., Goldstein, D. V., Yarygin, K. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Care and treatment Cell Biology Cell Differentiation Development and progression Genetic Vectors - chemistry Genetic Vectors - metabolism Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - transplantation Internal Medicine Ischemia Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Laboratory Medicine Lentivirus - genetics Lentivirus - metabolism Medical research Medicine, Experimental Methods Nervous system diseases Neural Stem Cells - cytology Neural Stem Cells - metabolism Neural Stem Cells - transplantation Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Pathology Precision Medicine - methods Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Retroviridae - genetics Retroviridae - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem Cell Transplantation - methods Stem cells Transduction, Genetic - methods Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Transplantation
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Zusammenfassung:	The use of induced pluripotent stem cells (IPSC) is a promising approach to the therapy of CNS diseases. The undeniable advantage of IPSC technology is the possibility of obtaining practically all types of somatic cells for autologous transplantation bypassing bioethical problems. The review presents integrative and non-integrative methods for obtaining IPSC and the ways of their in vitro and in vivo application for the study and treatment of neurological diseases.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-020-04754-4