l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-04, Vol.56 (27), p.3919-3922
Hauptverfasser: Guo, Wenna, Chen, Zengzhen, Tan, Longfei, Wu, Qiong, Ren, Xiangling, Fu, Changhui, Du, Yongxing, Ren, Jun, Meng, Xianwei
Format: Artikel
Sprache:eng
Schlagworte:
Acid resistance
Chemotherapy
Drug delivery systems
Growth factors
Lung cancer
Metal-organic frameworks
Nanoparticles
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Zusammenfassung:We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09712k