Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21

Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21

The molecular basis of type 1 autoimmune pancreatitis (AIP) remains unclear. Recent attention on the role of extracellular vesicles microRNA (EV miRNA) in immune homeostasis has prompted us to perform an extensive miRNA screening of serum-derived EV in AIP. EV miRNA expression was analyzed using mic...

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Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020-04, Vol.20 (3), p.318-324
Hauptverfasser: Nakamaru, Koh, Tomiyama, Takashi, Kobayashi, Sanshiro, Ikemune, Manami, Tsukuda, Satoshi, Ito, Takashi, Tanaka, Toshihiro, Yamaguchi, Takashi, Ando, Yugo, Ikeura, Tsukasa, Fukui, Toshiro, Nishio, Akiyoshi, Takaoka, Makoto, Uchida, Kazushige, Leung, Patrick S.C., Gershwin, M.E., Okazaki, Kazuichi
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Autoimmune Pancreatitis - genetics
Cohort Studies
Disease
Extracellular vesicles
Extracellular Vesicles - genetics
Female
Gene Expression - genetics
Gene Expression Profiling
Homeostasis
Humans
Hybridization
In situ hybridization
Inflammation
Inflammatory cell
Male
Microarray
MicroRNAs
MicroRNAs - biosynthesis
MicroRNAs - genetics
Middle Aged
miRNA
Nematodes
Pancreas
Pancreas - metabolism
Pancreatitis
Polymerase chain reaction
RT-PCR
Signal Transduction - genetics
Up-Regulation - genetics
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Zusammenfassung:The molecular basis of type 1 autoimmune pancreatitis (AIP) remains unclear. Recent attention on the role of extracellular vesicles microRNA (EV miRNA) in immune homeostasis has prompted us to perform an extensive miRNA screening of serum-derived EV in AIP. EV miRNA expression was analyzed using microarrays in AIP, chronic pancreatitis (CP), and healthy adult (HC) samples (n = 10 from each group). Differences in signals, > 3 or
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2020.02.012