Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway
Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the Alpinia oxyphylla–Schisandra chinensis herb pair (ASHP) for finding a candidate of AD...
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| Veröffentlicht in: | Neuromolecular medicine 2020-09, Vol.22 (3), p.370-383 |
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| creator | Qi, Yu Jing, Huiting Cheng, Xinhui Yan, Tingxu Xiao, Feng Wu, Bo Bi, Kaishun Jia, Ying |
| description | Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the
Alpinia oxyphylla–Schisandra chinensis
herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and neurodegeneration, and revealing the possible mechanism. In this study, an amyloid-β (Aβ) induced AD model was established in mice via intracerebroventricular injection. The Y-maze test and Morris water maze test were carried out to observe the behavioral change of mice, which showed that ASHP significantly ameliorated cognitive impairment. In addition, ASHP reduced amyloid-β deposition and downregulated the hyperphosphorylation of tau via immunofluorescence assay and western blot analysis, respectively. Subsequently we focused on the PI3K/Akt pathway that is a classical pathway related to nervous system diseases. It also noticeably ASHP improved the histopathological changes in the hippocampus and cortex. Moreover, it was found that ASHP could upregulate the PI3K/Akt/Gsk-3β/CREB signaling pathway in N2a-SwedAPP cells. Taken together, it suggests that ASHP might reverse cognitive deficits and neurodegeneration via PI3K/Akt/Gsk-3β/CREB pathway. |
| doi_str_mv | 10.1007/s12017-020-08595-2 |
| format | Article |
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Alpinia oxyphylla–Schisandra chinensis
herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and neurodegeneration, and revealing the possible mechanism. In this study, an amyloid-β (Aβ) induced AD model was established in mice via intracerebroventricular injection. The Y-maze test and Morris water maze test were carried out to observe the behavioral change of mice, which showed that ASHP significantly ameliorated cognitive impairment. In addition, ASHP reduced amyloid-β deposition and downregulated the hyperphosphorylation of tau via immunofluorescence assay and western blot analysis, respectively. Subsequently we focused on the PI3K/Akt pathway that is a classical pathway related to nervous system diseases. It also noticeably ASHP improved the histopathological changes in the hippocampus and cortex. Moreover, it was found that ASHP could upregulate the PI3K/Akt/Gsk-3β/CREB signaling pathway in N2a-SwedAPP cells. Taken together, it suggests that ASHP might reverse cognitive deficits and neurodegeneration via PI3K/Akt/Gsk-3β/CREB pathway.</description><identifier>ISSN: 1535-1084</identifier><identifier>EISSN: 1559-1174</identifier><identifier>DOI: 10.1007/s12017-020-08595-2</identifier><identifier>PMID: 32140977</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Alpinia ; Alzheimer's disease ; Amyloid ; Biomedical and Life Sciences ; Biomedicine ; Classical pathway ; Cognitive ability ; Cyclic AMP response element-binding protein ; Herbs ; Immunofluorescence ; Internal Medicine ; Nervous system ; Nervous system diseases ; Neurodegeneration ; Neurodegenerative diseases ; Neurology ; Neurosciences ; Original Paper ; Phosphorylation ; Schisandra chinensis ; Signal transduction ; Tau protein ; Traditional Chinese medicine</subject><ispartof>Neuromolecular medicine, 2020-09, Vol.22 (3), p.370-383</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-228996468ac60abb74c89d39eb7f62ca089963993aa3572830aa5ea976a99c223</citedby><cites>FETCH-LOGICAL-c375t-228996468ac60abb74c89d39eb7f62ca089963993aa3572830aa5ea976a99c223</cites><orcidid>0000-0002-1289-4350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12017-020-08595-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12017-020-08595-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32140977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Yu</creatorcontrib><creatorcontrib>Jing, Huiting</creatorcontrib><creatorcontrib>Cheng, Xinhui</creatorcontrib><creatorcontrib>Yan, Tingxu</creatorcontrib><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Wu, Bo</creatorcontrib><creatorcontrib>Bi, Kaishun</creatorcontrib><creatorcontrib>Jia, Ying</creatorcontrib><title>Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway</title><title>Neuromolecular medicine</title><addtitle>Neuromol Med</addtitle><addtitle>Neuromolecular Med</addtitle><description>Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the
Alpinia oxyphylla–Schisandra chinensis
herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and neurodegeneration, and revealing the possible mechanism. In this study, an amyloid-β (Aβ) induced AD model was established in mice via intracerebroventricular injection. The Y-maze test and Morris water maze test were carried out to observe the behavioral change of mice, which showed that ASHP significantly ameliorated cognitive impairment. In addition, ASHP reduced amyloid-β deposition and downregulated the hyperphosphorylation of tau via immunofluorescence assay and western blot analysis, respectively. Subsequently we focused on the PI3K/Akt pathway that is a classical pathway related to nervous system diseases. It also noticeably ASHP improved the histopathological changes in the hippocampus and cortex. Moreover, it was found that ASHP could upregulate the PI3K/Akt/Gsk-3β/CREB signaling pathway in N2a-SwedAPP cells. Taken together, it suggests that ASHP might reverse cognitive deficits and neurodegeneration via PI3K/Akt/Gsk-3β/CREB pathway.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Alpinia</subject><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Classical pathway</subject><subject>Cognitive ability</subject><subject>Cyclic AMP response element-binding protein</subject><subject>Herbs</subject><subject>Immunofluorescence</subject><subject>Internal Medicine</subject><subject>Nervous system</subject><subject>Nervous system diseases</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Phosphorylation</subject><subject>Schisandra chinensis</subject><subject>Signal transduction</subject><subject>Tau protein</subject><subject>Traditional Chinese medicine</subject><issn>1535-1084</issn><issn>1559-1174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu1DAUhq2Kqjd4ARbIEhs2ZnxJ4ngZhl5GrUTFZW2dOJ6O24wztZO22bHhCXiTPkgfgifBw7RUYsHKRzqffx-fD6HXjL5nlMpJZJwySSinhJa5ygnfQnsszxVhTGYv1rXICaNltov2Y7yklHPG2A7aFZxlVEm5h35U7cp5B7i7G1eLsW3h1_efX8zCRfBNAJwqb310EZ_YUONzcAFXbWtvHPQ24mo5tp1ryMM9nvlmMLbB0-7Cu97dWPzRzp1xfcQJxuczcTqprvrJcbwi4uF-Mv18-CHl9YtbGF-i7Tm00b56PA_Qt6PDr9MTcvbpeDatzogRMu8J56VSRVaUYAoKdS0zU6pGKFvLecEN0HVbKCUARC55KShAbkHJApQynIsD9G6Tuwrd9WBjr5cuGpt-7W03RM2FzESRtlYm9O0_6GU3BJ-m0zwTnMu0Y5oovqFM6GIMdq5XwS0hjJpRvZakN5J0kqT_SNLrKd48Rg_10jZ_rzxZSYDYADG1_IUNz2__J_Y3uTSdrA</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Qi, Yu</creator><creator>Jing, Huiting</creator><creator>Cheng, Xinhui</creator><creator>Yan, Tingxu</creator><creator>Xiao, Feng</creator><creator>Wu, Bo</creator><creator>Bi, Kaishun</creator><creator>Jia, Ying</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1289-4350</orcidid></search><sort><creationdate>20200901</creationdate><title>Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway</title><author>Qi, Yu ; Jing, Huiting ; Cheng, Xinhui ; Yan, Tingxu ; Xiao, Feng ; Wu, Bo ; Bi, Kaishun ; Jia, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-228996468ac60abb74c89d39eb7f62ca089963993aa3572830aa5ea976a99c223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Alpinia</topic><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Classical pathway</topic><topic>Cognitive ability</topic><topic>Cyclic AMP response element-binding protein</topic><topic>Herbs</topic><topic>Immunofluorescence</topic><topic>Internal Medicine</topic><topic>Nervous system</topic><topic>Nervous system diseases</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Phosphorylation</topic><topic>Schisandra chinensis</topic><topic>Signal transduction</topic><topic>Tau protein</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Yu</creatorcontrib><creatorcontrib>Jing, Huiting</creatorcontrib><creatorcontrib>Cheng, Xinhui</creatorcontrib><creatorcontrib>Yan, Tingxu</creatorcontrib><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Wu, Bo</creatorcontrib><creatorcontrib>Bi, Kaishun</creatorcontrib><creatorcontrib>Jia, Ying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuromolecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Yu</au><au>Jing, Huiting</au><au>Cheng, Xinhui</au><au>Yan, Tingxu</au><au>Xiao, Feng</au><au>Wu, Bo</au><au>Bi, Kaishun</au><au>Jia, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway</atitle><jtitle>Neuromolecular medicine</jtitle><stitle>Neuromol Med</stitle><addtitle>Neuromolecular Med</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>22</volume><issue>3</issue><spage>370</spage><epage>383</epage><pages>370-383</pages><issn>1535-1084</issn><eissn>1559-1174</eissn><abstract>Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the
Alpinia oxyphylla–Schisandra chinensis
herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function and neurodegeneration, and revealing the possible mechanism. In this study, an amyloid-β (Aβ) induced AD model was established in mice via intracerebroventricular injection. The Y-maze test and Morris water maze test were carried out to observe the behavioral change of mice, which showed that ASHP significantly ameliorated cognitive impairment. In addition, ASHP reduced amyloid-β deposition and downregulated the hyperphosphorylation of tau via immunofluorescence assay and western blot analysis, respectively. Subsequently we focused on the PI3K/Akt pathway that is a classical pathway related to nervous system diseases. It also noticeably ASHP improved the histopathological changes in the hippocampus and cortex. Moreover, it was found that ASHP could upregulate the PI3K/Akt/Gsk-3β/CREB signaling pathway in N2a-SwedAPP cells. Taken together, it suggests that ASHP might reverse cognitive deficits and neurodegeneration via PI3K/Akt/Gsk-3β/CREB pathway.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32140977</pmid><doi>10.1007/s12017-020-08595-2</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1289-4350</orcidid></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Alpinia Alzheimer's disease Amyloid Biomedical and Life Sciences Biomedicine Classical pathway Cognitive ability Cyclic AMP response element-binding protein Herbs Immunofluorescence Internal Medicine Nervous system Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurology Neurosciences Original Paper Phosphorylation Schisandra chinensis Signal transduction Tau protein Traditional Chinese medicine |
| title | Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway |
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