Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage
To investigate the effect of intracranial pressure (ICP) monitoring on the functional outcome of patients with hypertension-related spontaneous intracerebral hemorrhage (ICH). We included 196 patients with Glasgow Coma Scale (GCS) scores of 3–12 in this observational study, of which 103 underwent IC...
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| Veröffentlicht in: | Translational stroke research 2020-12, Vol.11 (6), p.1253-1263 |
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| creator | Ren, Junwei Wu, Xing Huang, Jiongwei Cao, Xudong Yuan, Qiang Zhang, Dalong Du, Zhuoying Zhong, Ping Hu, Jin |
| description | To investigate the effect of intracranial pressure (ICP) monitoring on the functional outcome of patients with hypertension-related spontaneous intracerebral hemorrhage (ICH). We included 196 patients with Glasgow Coma Scale (GCS) scores of 3–12 in this observational study, of which 103 underwent ICP monitors. Binary and ordinal regression analyses were used to estimate the effect of ICP monitoring on the functional outcome. The rate of adverse events, blood pressure control, and length of hospitalization were compared between the two groups. ICP monitoring had a significant impact on the clinical outcome of patients by shifting the Extended Glasgow Outcome Scale (GOS-E) scores in a favorable direction (
p
= 0.027) and reducing mortality at discharge (
p
= 0.004) and 6 months later (
p
= 0.02). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.03). However, subgroup analysis showed that no relationship between ICP monitoring and clinical outcome was found for patients with GCS scores of 3–8. For patients with GCS scores of 9–12, the distribution of GOS-E scores at 6 months shifted in a favorable direction in the ICP-monitored group (
p
= 0.001). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.01). The mortality at discharge and 6 months later was also lower in the ICP-monitored group. Thus, our study supports the value of ICP monitoring in hypertension-related ICH patients with GCS scores of 3–12, especially those with GCS scores of 9–12. |
| doi_str_mv | 10.1007/s12975-020-00798-w |
| format | Article |
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p
= 0.027) and reducing mortality at discharge (
p
= 0.004) and 6 months later (
p
= 0.02). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.03). However, subgroup analysis showed that no relationship between ICP monitoring and clinical outcome was found for patients with GCS scores of 3–8. For patients with GCS scores of 9–12, the distribution of GOS-E scores at 6 months shifted in a favorable direction in the ICP-monitored group (
p
= 0.001). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.01). The mortality at discharge and 6 months later was also lower in the ICP-monitored group. Thus, our study supports the value of ICP monitoring in hypertension-related ICH patients with GCS scores of 3–12, especially those with GCS scores of 9–12.</description><identifier>ISSN: 1868-4483</identifier><identifier>EISSN: 1868-601X</identifier><identifier>DOI: 10.1007/s12975-020-00798-w</identifier><identifier>PMID: 32144586</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Cardiology ; Catheters ; Clinical Neurology ; Hematoma ; Hemorrhage ; Hospitalization ; Hydrocephalus ; Hypertension ; Intracranial pressure ; Life Sciences & Biomedicine ; Mortality ; Neurology ; Neurosciences ; Neurosciences & Neurology ; Neurosurgery ; Nosocomial infections ; Original Article ; Patients ; Regression analysis ; Science & Technology ; Stroke ; Surgery ; Vascular Surgery</subject><ispartof>Translational stroke research, 2020-12, Vol.11 (6), p.1253-1263</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>21</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000562297000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-4765db227df0ab0bfe9d85b7ac3650e01ff7c648e7e7ab7cd169e1cf33dca0c73</citedby><cites>FETCH-LOGICAL-c375t-4765db227df0ab0bfe9d85b7ac3650e01ff7c648e7e7ab7cd169e1cf33dca0c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12975-020-00798-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919733217?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,21395,21396,27931,27932,28255,33537,33538,33751,33752,41495,42564,43666,43812,51326,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32144586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Junwei</creatorcontrib><creatorcontrib>Wu, Xing</creatorcontrib><creatorcontrib>Huang, Jiongwei</creatorcontrib><creatorcontrib>Cao, Xudong</creatorcontrib><creatorcontrib>Yuan, Qiang</creatorcontrib><creatorcontrib>Zhang, Dalong</creatorcontrib><creatorcontrib>Du, Zhuoying</creatorcontrib><creatorcontrib>Zhong, Ping</creatorcontrib><creatorcontrib>Hu, Jin</creatorcontrib><title>Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage</title><title>Translational stroke research</title><addtitle>Transl. Stroke Res</addtitle><addtitle>TRANSL STROKE RES</addtitle><addtitle>Transl Stroke Res</addtitle><description>To investigate the effect of intracranial pressure (ICP) monitoring on the functional outcome of patients with hypertension-related spontaneous intracerebral hemorrhage (ICH). We included 196 patients with Glasgow Coma Scale (GCS) scores of 3–12 in this observational study, of which 103 underwent ICP monitors. Binary and ordinal regression analyses were used to estimate the effect of ICP monitoring on the functional outcome. The rate of adverse events, blood pressure control, and length of hospitalization were compared between the two groups. ICP monitoring had a significant impact on the clinical outcome of patients by shifting the Extended Glasgow Outcome Scale (GOS-E) scores in a favorable direction (
p
= 0.027) and reducing mortality at discharge (
p
= 0.004) and 6 months later (
p
= 0.02). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.03). However, subgroup analysis showed that no relationship between ICP monitoring and clinical outcome was found for patients with GCS scores of 3–8. For patients with GCS scores of 9–12, the distribution of GOS-E scores at 6 months shifted in a favorable direction in the ICP-monitored group (
p
= 0.001). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.01). The mortality at discharge and 6 months later was also lower in the ICP-monitored group. Thus, our study supports the value of ICP monitoring in hypertension-related ICH patients with GCS scores of 3–12, especially those with GCS scores of 9–12.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Catheters</subject><subject>Clinical Neurology</subject><subject>Hematoma</subject><subject>Hemorrhage</subject><subject>Hospitalization</subject><subject>Hydrocephalus</subject><subject>Hypertension</subject><subject>Intracranial pressure</subject><subject>Life Sciences & Biomedicine</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Neurosurgery</subject><subject>Nosocomial infections</subject><subject>Original Article</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Science & Technology</subject><subject>Stroke</subject><subject>Surgery</subject><subject>Vascular Surgery</subject><issn>1868-4483</issn><issn>1868-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkl1r1TAYx4Mobsx9AS-k4I0g1by0SXt5ODjPYGPDF_AuJOnTLaNNapJ62Kfxq5quxwleiLnJC7__k3-efxB6SfA7grF4HwltRV1iisu8bZty_wQdk4Y3Jcfk29PDuqoadoROY7zDeTBS8Yo9R0eMkqqqG36Mfp67FJQJylk1FNcBYpwDFJfe2eSDdTflxnbQFZfKqRsYwaViE6M3VqV8urfptjhTP3xQeoDiak7GjxAL64prlWym48rs7icICVy03pWfYHhQf568S8qBn2Ox2oAAOmQfOxh9CLf5xhfoWa-GCKeH-QR9PfvwZbsrL64-nm83F6Vhok5lJXjdaUpF12Olse6h7ZpaC2UYrzFg0vfC8KoBAUJpYTrCWyCmZ6wzChvBTtCbte4U_PcZYpKjjQaGYfUnKRMVqynlC_r6L_TOz8Fld5K2pBUsd3eh6EqZ4GMM0Msp2FGFe0mwXBKUa4IyJygfEpT7LHp1KD3rEbpHye-8MtCswB6076PJLTbwiOWIa05z1SVsTLY25RC82_rZpSx9-__STLOVjtPyCyD8eeQ__P8Cl2HMPQ</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Ren, Junwei</creator><creator>Wu, Xing</creator><creator>Huang, Jiongwei</creator><creator>Cao, Xudong</creator><creator>Yuan, Qiang</creator><creator>Zhang, Dalong</creator><creator>Du, Zhuoying</creator><creator>Zhong, Ping</creator><creator>Hu, Jin</creator><general>Springer US</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage</title><author>Ren, Junwei ; Wu, Xing ; Huang, Jiongwei ; Cao, Xudong ; Yuan, Qiang ; Zhang, Dalong ; Du, Zhuoying ; Zhong, Ping ; Hu, Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4765db227df0ab0bfe9d85b7ac3650e01ff7c648e7e7ab7cd169e1cf33dca0c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Catheters</topic><topic>Clinical Neurology</topic><topic>Hematoma</topic><topic>Hemorrhage</topic><topic>Hospitalization</topic><topic>Hydrocephalus</topic><topic>Hypertension</topic><topic>Intracranial pressure</topic><topic>Life Sciences & Biomedicine</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Neurosurgery</topic><topic>Nosocomial infections</topic><topic>Original Article</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Science & Technology</topic><topic>Stroke</topic><topic>Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Junwei</creatorcontrib><creatorcontrib>Wu, Xing</creatorcontrib><creatorcontrib>Huang, Jiongwei</creatorcontrib><creatorcontrib>Cao, Xudong</creatorcontrib><creatorcontrib>Yuan, Qiang</creatorcontrib><creatorcontrib>Zhang, Dalong</creatorcontrib><creatorcontrib>Du, Zhuoying</creatorcontrib><creatorcontrib>Zhong, Ping</creatorcontrib><creatorcontrib>Hu, Jin</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Translational stroke research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Junwei</au><au>Wu, Xing</au><au>Huang, Jiongwei</au><au>Cao, Xudong</au><au>Yuan, Qiang</au><au>Zhang, Dalong</au><au>Du, Zhuoying</au><au>Zhong, Ping</au><au>Hu, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage</atitle><jtitle>Translational stroke research</jtitle><stitle>Transl. Stroke Res</stitle><stitle>TRANSL STROKE RES</stitle><addtitle>Transl Stroke Res</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>11</volume><issue>6</issue><spage>1253</spage><epage>1263</epage><pages>1253-1263</pages><issn>1868-4483</issn><eissn>1868-601X</eissn><abstract>To investigate the effect of intracranial pressure (ICP) monitoring on the functional outcome of patients with hypertension-related spontaneous intracerebral hemorrhage (ICH). We included 196 patients with Glasgow Coma Scale (GCS) scores of 3–12 in this observational study, of which 103 underwent ICP monitors. Binary and ordinal regression analyses were used to estimate the effect of ICP monitoring on the functional outcome. The rate of adverse events, blood pressure control, and length of hospitalization were compared between the two groups. ICP monitoring had a significant impact on the clinical outcome of patients by shifting the Extended Glasgow Outcome Scale (GOS-E) scores in a favorable direction (
p
= 0.027) and reducing mortality at discharge (
p
= 0.004) and 6 months later (
p
= 0.02). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.03). However, subgroup analysis showed that no relationship between ICP monitoring and clinical outcome was found for patients with GCS scores of 3–8. For patients with GCS scores of 9–12, the distribution of GOS-E scores at 6 months shifted in a favorable direction in the ICP-monitored group (
p
= 0.001). The rate of favorable outcome at 6 months was higher in the ICP-monitored group (
p
= 0.01). The mortality at discharge and 6 months later was also lower in the ICP-monitored group. Thus, our study supports the value of ICP monitoring in hypertension-related ICH patients with GCS scores of 3–12, especially those with GCS scores of 9–12.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32144586</pmid><doi>10.1007/s12975-020-00798-w</doi><tpages>11</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Blood pressure Cardiology Catheters Clinical Neurology Hematoma Hemorrhage Hospitalization Hydrocephalus Hypertension Intracranial pressure Life Sciences & Biomedicine Mortality Neurology Neurosciences Neurosciences & Neurology Neurosurgery Nosocomial infections Original Article Patients Regression analysis Science & Technology Stroke Surgery Vascular Surgery |
| title | Intracranial Pressure Monitoring-Aided Management Associated with Favorable Outcomes in Patients with Hypertension-Related Spontaneous Intracerebral Hemorrhage |
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