Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex

Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-functionalized drugs. Antibodies against PEG-coated nanocarriers can accelerate their clearance, but their impact on nanodrug properties including nanocarrier integr...

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Veröffentlicht in:	ACS nano 2020-07, Vol.14 (7), p.7808-7822
Hauptverfasser:	Chen, Even, Chen, Bing-Mae, Su, Yu-Cheng, Chang, Yuan-Chih, Cheng, Tian-Lu, Barenholz, Yechezekel, Roffler, Steve R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Complement Membrane Attack Complex Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Drug Liberation Humans Liposomes Polyethylene Glycols Rats
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