Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression

Simplified treatment regimens for HIV management may increase adherence. In this open-label, randomized, controlled trial, longer-acting (monthly) injectable cabotegravir plus rilpivirine was compared with standard oral treatment. At 48 weeks, similar viral suppression was seen with the two regimens...

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Veröffentlicht in:	The New England journal of medicine 2020-03, Vol.382 (12), p.1112-1123
Hauptverfasser:	Swindells, Susan, Andrade-Villanueva, Jaime-Federico, Richmond, Gary J, Rizzardini, Giuliano, Baumgarten, Axel, Masiá, Mar, Latiff, Gulam, Pokrovsky, Vadim, Bredeek, Fritz, Smith, Graham, Cahn, Pedro, Kim, Yeon-Sook, Ford, Susan L, Talarico, Christine L, Patel, Parul, Chounta, Vasiliki, Crauwels, Herta, Parys, Wim, Vanveggel, Simon, Mrus, Joseph, Huang, Jenny, Harrington, Conn M, Hudson, Krischan J, Margolis, David A, Smith, Kimberly Y, Williams, Peter E, Spreen, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Anti-HIV Agents - blood Anti-Retroviral Agents - therapeutic use Antiretroviral drugs Antiretroviral therapy CD4 Lymphocyte Count Drug dosages Drug Resistance, Viral - genetics Drug therapy Drug Therapy, Combination FDA approval Female HIV HIV Infections - drug therapy HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus Humans Infections Injection Injections, Intramuscular - adverse effects Integrase Maintenance Chemotherapy Male Middle Aged Mutation Patient Reported Outcome Measures Patient satisfaction Patients Pyridones - administration & dosage Pyridones - adverse effects Pyridones - blood Ribonucleic acid Rilpivirine - administration & dosage Rilpivirine - adverse effects Rilpivirine - blood RNA RNA, Viral - blood Statistical analysis Viral Load
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Beschreibung
Zusammenfassung:	Simplified treatment regimens for HIV management may increase adherence. In this open-label, randomized, controlled trial, longer-acting (monthly) injectable cabotegravir plus rilpivirine was compared with standard oral treatment. At 48 weeks, similar viral suppression was seen with the two regimens.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1904398