Unlocking the direct photocatalytic difluoromethylation of C[double bond, length as m-dash]N bonds

Unlocking the direct photocatalytic difluoromethylation of C[double bond, length as m-dash]N bonds

The current study presents a direct CF2H radical addition to C[double bond, length as m-dash]N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenz...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (26), p.3769-3772
Hauptverfasser: Garrido-Castro, Alberto F, Gini, Andrea, Maestro, M Carmen, Alemán, José
Format: Artikel
Sprache:eng
Schlagworte:
Photocatalysis
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Zusammenfassung:The current study presents a direct CF2H radical addition to C[double bond, length as m-dash]N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01353f