Relationship of depressive symptoms with arterial stiffness and carotid atherosclerotic burden in the Corinthia study

Abstract Background It has been long hypothesized that emotional factors and depression may play role in the development of cardiovascular diseases. Aim The aim of this study was to examine the association between depression, arterial stiffness and atheromatic burden in carotid arteries. Design and...

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Veröffentlicht in:QJM : An International Journal of Medicine 2020-09, Vol.113 (9), p.633-642
Hauptverfasser: Oikonomou, E, Vogiatzi, G, Lazaros, G, Tsalamandris, S, Goliopoulou, A, Mystakidou, V, Theofilis, P, Christoforatou, E, Chasikidis, C, Tousoulis, D
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Sprache:eng
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Zusammenfassung:Abstract Background It has been long hypothesized that emotional factors and depression may play role in the development of cardiovascular diseases. Aim The aim of this study was to examine the association between depression, arterial stiffness and atheromatic burden in carotid arteries. Design and methods Corinthia study is a cross-sectional epidemiological study conducted in subjects aged 40–99 years, inhabitants of the homonym region of Greece. Intima media thickness (IMT) was measured in the left and right common carotid artery, carotid bulb and internal carotid artery. The average of the measurements (mean IMT) and the maximum IMT were determined as the representative value of carotid atherosclerosis burden. Pulse wave velocity was used to evaluate arterial stiffness. The Zung Self-Rating Depression Scale was used to evaluate depressive symptoms in subjects 65 years. Results In this analysis, we included data from 1510 participants. In older subjects (i.e. >65 years), maximum IMT was significantly increased in subjects with depression compared to those without (1.57 ± 0.97 mm vs. 1.74 ± 1.05 mm, P = 0.04). Similarly, the prevalence of atheromatic plaques was higher in subjects with depression (46% vs. 34%, P = 0.005). In the younger subgroup (
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcaa079