PNPLA3 I148M gene variant and chronic kidney disease in type 2 diabetic patients with NAFLD: Clinical and experimental findings

Background and Aims Emerging evidence suggests an association between patatin‐like phospholipase domain‐containing protein‐3 (PNPLA3) rs738409 (I148M protein variant) and risk of chronic kidney disease (CKD), but the mechanisms underpinning this association are poorly understood. Methods We studied...

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Veröffentlicht in:	Liver international 2020-05, Vol.40 (5), p.1130-1141
Hauptverfasser:	Mantovani, Alessandro, Taliento, Alice, Zusi, Chiara, Baselli, Guido, Prati, Daniele, Granata, Simona, Zaza, Gianluigi, Colecchia, Antonio, Maffeis, Claudio, Byrne, Christopher D., Valenti, Luca, Targher, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	adiponutrin Cell lines Diabetes mellitus (non-insulin dependent) Fatty liver Gene expression Genotypes Glomerular filtration rate Health risks Hepatocytes Homozygosity Human tissues Kidney diseases kidney dysfunction Kidneys Liver Liver diseases NAFLD Phospholipase Proteins Renal cortex renal podocytes Risk analysis Risk factors Stellate cells Stiffness Vibration
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Zusammenfassung:	Background and Aims Emerging evidence suggests an association between patatin‐like phospholipase domain‐containing protein‐3 (PNPLA3) rs738409 (I148M protein variant) and risk of chronic kidney disease (CKD), but the mechanisms underpinning this association are poorly understood. Methods We studied 157 patients with type 2 diabetes (T2DM) who underwent ultrasonography and vibration‐controlled transient elastography for diagnosing nonalcoholic fatty liver disease (NAFLD). CKD was defined as estimated glomerular filtration rate (e‐GFR)
ISSN:	1478-3223 1478-3231
DOI:	10.1111/liv.14419