Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents

Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents

The adaptive immune system of cartilaginous fish (Elasmobranchii), comprising of classical hetero-tetrameric antibodies, is enhanced through the presence of a naturally occurring homodimeric antibody-like immunoglobulin-the new antigen receptor (IgNAR). The binding site of the IgNAR variable single-...

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Veröffentlicht in:Protein engineering, design and selection design and selection, 2019-12, Vol.32 (9), p.385-399
Hauptverfasser: Buschhaus, Magdalena J, Becker, Stefan, Porter, Andrew J, Barelle, Caroline J
Format: Artikel
Sprache:eng
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Zusammenfassung:The adaptive immune system of cartilaginous fish (Elasmobranchii), comprising of classical hetero-tetrameric antibodies, is enhanced through the presence of a naturally occurring homodimeric antibody-like immunoglobulin-the new antigen receptor (IgNAR). The binding site of the IgNAR variable single-domain (VNAR) offers advantages of reduced size (
ISSN:1741-0126
1741-0134
DOI:10.1093/protein/gzaa002