Equol Inhibits Mushroom Tyrosinase in Vitro through Tight Binding

Equol Inhibits Mushroom Tyrosinase in Vitro through Tight Binding

Equol, an intestinal metabolite of daidzein, inhibited more potently mushroom tyrosinase in vitro than other inhibitors, genistein and kojic acid. We investigated the mechanism underlying tyrosinase inhibition by equol. Treating racemic equol with tyrosinase produced 3ʹ-hydroxyequol. Because the opt...

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Veröffentlicht in:Biological & pharmaceutical bulletin 2020/03/01, Vol.43(3), pp.550-553
Hauptverfasser: Niwa, Toshio, Akiyama, Haruna, Echikawa, Madoka, Yokoyama, Shin-ichiro, Mochizuki, Mika, Osawa, Toshihiko
Format: Artikel
Sprache:eng
Schlagworte:
Daidzein
enzyme-linked immunosorbent assay (ELISA)
equol
Genistein
Intestine
Kojic acid
Metabolites
Monoclonal antibodies
tyrosinase
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Zusammenfassung:Equol, an intestinal metabolite of daidzein, inhibited more potently mushroom tyrosinase in vitro than other inhibitors, genistein and kojic acid. We investigated the mechanism underlying tyrosinase inhibition by equol. Treating racemic equol with tyrosinase produced 3ʹ-hydroxyequol. Because the optical activity of the product showed
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b19-00756