Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

Objectives To explore the associations of TNF-α −308 G>A (rs1800629) and TNF-β 252 A>G (rs909253) with physical function and plasma B-type natriuretic peptide (BNP). Methods Data of 1747 community-dwelling elders from the ageing arm of the Rugao Longevity and Ageing Study was used. Physical function was measured by handgrip strength, Timed Up and Go (TUG) test and 5-meter walking test (5MWT). Results AA genotype of the TNF-α −308 G>A was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=5.75 and 5.70, respectively, pG polymorphism, GG genotype was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=1.55 and 0.83, respectively, pG also interacted with elevated BNP to be associated with greater odds of physical function measurements.