Prebiotic potencial of juçara berry on changes in gut bacteria and acetate of individuals with obesity

Purpose Whole plant foods can be fermentable by SCFA-producing bacteria and positively influence host adipose tissue development and obesity related-metabolic disorders, conferring a prebiotic role. Considering the juçara berry composition, rich in fiber and polyphenols, we hypothesized the probable...

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Veröffentlicht in:European journal of nutrition 2020-12, Vol.59 (8), p.3767-3778
Hauptverfasser: Jamar, Giovana, Santamarina, Aline Boveto, Casagrande, Breno Picin, Estadella, Débora, de Rosso, Veridiana Vera, Wagner, Roger, Fagundes, Mariane Bittencourt, Pisani, Luciana Pellegrini
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Sprache:eng
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Zusammenfassung:Purpose Whole plant foods can be fermentable by SCFA-producing bacteria and positively influence host adipose tissue development and obesity related-metabolic disorders, conferring a prebiotic role. Considering the juçara berry composition, rich in fiber and polyphenols, we hypothesized the probable prebiotic role of juçara in individuals with obesity. Methods It was a randomized double-blind placebo-controlled trial with 35 volunteers with obesity I and II of both sexes aged from 31 to 59 years, divided into juçara group (5 g lyophilized juçara) or placebo group (5 g of maltodextrin) for 6 weeks. Before and after supplementation, food intake and blood and stool samples were collected to evaluate serum LPS, SCFA, and microbial bacteria. Results Significant increase in fecal acetate ( g  = 0.809; p  = 0.038) and in relative abundance of A. muciniphila, Bifidobacterium spp. and C. coccoides were observed in response to juçara supplementation ( Δ % = 239.6%, 182.6%, and 214%, respectively), with a significant mediator role of Bifidobacterium spp. in high amounts of fecal acetate ( z  = 2.925; p  = 0.003). To certify the prebiotic role of juçara, the averages were adjusted for total fiber intake; and there was no effect of the fiber intake on the SCFA nor on the intestinal bacteria. Conclusion Juçara berry may haveprebiotic function, with emphasis on the bifidogenic effect, leading to increased excretion of acetate.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-020-02208-1