Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

It is well established that asthma is common in patients with atopic dermatitis (AD). We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma. At least 2 authors independ...

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Veröffentlicht in:Journal of the American Academy of Dermatology 2021-02, Vol.84 (2), p.471-478
Hauptverfasser: Ravnborg, Nanna, Ambikaibalan, Danni, Agnihotri, Gaurav, Price, Shmuel, Rastogi, Supriya, Patel, Kevin R., Singam, Vivek, Andersen, Yuki, Halling, Anne-Sofie, Silverberg, Jonathan I., Egeberg, Alexander, Thyssen, Jacob P.
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Sprache:eng
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Zusammenfassung:It is well established that asthma is common in patients with atopic dermatitis (AD). We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma. At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality. The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47). The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed. Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2020.02.055