Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study
Background The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurren...
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| Veröffentlicht in: | World journal of surgery 2020-06, Vol.44 (6), p.1966-1974 |
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| container_title | World journal of surgery |
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| creator | Lim, Chetana Goumard, Claire Casellas-Robert, Margarida Lopez-Ben, Santiago Lladó, Laura Busquets, Juli Salloum, Chady Albiol-Quer, Maria Teresa Castro-Gutiérrez, Ernest Rosmorduc, Olivier Feray, Cyrille Ramos, Emilio Figueras, Joan Scatton, Olivier Azoulay, Daniel |
| description | Background
The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC.
Methods
All initially transplantable HCC patients undergoing hepatectomy with either narrow ( |
| doi_str_mv | 10.1007/s00268-020-05424-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2364046346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2364046346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4267-e9ee0aeedb505401e865182b69d732d10265e08c7fbbb2f7ff7cdc17d870e4ca3</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EosvCC3BAlrhwCUzsOMn2tqwoXdRqEbuIY-Q4k60rx97aTqt9ON4NlxSQOCAkS5bG3z__eH5CXubwNgeo3gUAVtYZMMhAFKzI2CMyywvOMsYZf0xmwMtU5Dk_Ic9CuAbIqxLKp-SEM1iIWogZ-b4eDlJF6izdWOWM22slDd2MUbkBA5W2o2sb0cYsumznUUa6Hf2tvk2U6-kXDKiiTvJL6ffa0t55uvPShoORNsrWID3Hg4xOoTGjkZ6upFfaukHShC-NyVbJyU9WqfJZRp3sAr3T8YqutPdXLuhwSpf0cjRRq_SInm7j2B2fkye9NAFfPNxz8vXsw251nl1sPq5Xy4tMFaysMlwggkTsWpEWBTnWpchr1paLruKsy9MaBUKtqr5tW9ZXfV-pTuVVV1eAhZJ8Tt5MfQ_e3YwYYjPocP8hadGNoWFp0VCUPJ05ef0Xeu1Gb9N0iVqIQoiyFIliE6W8C8Fj3xy8HqQ_Njk09-E2U7hNCrf5GW5Sz8mrh9ZjO2D3W_IrzQScTsCdNnj8j5bNt0_b92cARVElMZ_EIensHv2fwf8x0w8By8Ol</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2395455665</pqid></control><display><type>article</type><title>Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Access via Wiley Online Library</source><creator>Lim, Chetana ; Goumard, Claire ; Casellas-Robert, Margarida ; Lopez-Ben, Santiago ; Lladó, Laura ; Busquets, Juli ; Salloum, Chady ; Albiol-Quer, Maria Teresa ; Castro-Gutiérrez, Ernest ; Rosmorduc, Olivier ; Feray, Cyrille ; Ramos, Emilio ; Figueras, Joan ; Scatton, Olivier ; Azoulay, Daniel</creator><creatorcontrib>Lim, Chetana ; Goumard, Claire ; Casellas-Robert, Margarida ; Lopez-Ben, Santiago ; Lladó, Laura ; Busquets, Juli ; Salloum, Chady ; Albiol-Quer, Maria Teresa ; Castro-Gutiérrez, Ernest ; Rosmorduc, Olivier ; Feray, Cyrille ; Ramos, Emilio ; Figueras, Joan ; Scatton, Olivier ; Azoulay, Daniel</creatorcontrib><description>Background
The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC.
Methods
All initially transplantable HCC patients undergoing hepatectomy with either narrow (<10 mm) or wide (≥10 mm) margins from 2007 to 2016 at four Western university centers were compared in terms of recurrence, transplantability of recurrence, recurrence-free survival (RFS), and intention-to-treat overall survival (ITT-OS). Independent predictors of non-transplantability of recurrence were assessed.
Results
This study included 187 patients (narrow group,
n
= 107 vs. wide group,
n
= 80). Recurrence was significantly more frequent in the narrow margin group (44% vs. 26%;
p
= 0.01) with a shorter RFS (
p
= 0.03). The transplantability of recurrence and ITT-OS were, however, not different between the two groups. The presence of satellite nodules on the resected specimens emerged as the sole independent predictor of non-transplantability of tumor recurrence. The stratification of the analysis according to the presence of cirrhosis achieved essentially the same results as in the whole study population.
Conclusions
Narrow margin was associated with a higher tumor recurrence rate and a shorter RFS for patients with initially transplantable HCC. However, transplantability of recurrence and long-term ITT-OS were not impaired.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-020-05424-2</identifier><identifier>PMID: 32095855</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Aged ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cardiac Surgery ; Cirrhosis ; Female ; General Surgery ; Hepatectomy ; Hepatectomy - methods ; Hepatocellular carcinoma ; Humans ; Intention to Treat Analysis ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Neoplasms - complications ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation ; Male ; Margins of Excision ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - surgery ; Nodules ; Original Scientific Report ; Population studies ; Salvage Therapy ; Surgery ; Survival ; Survival Rate ; Thoracic Surgery ; Treatment Outcome ; Tumors ; Vascular Surgery</subject><ispartof>World journal of surgery, 2020-06, Vol.44 (6), p.1966-1974</ispartof><rights>Société Internationale de Chirurgie 2020</rights><rights>2020 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>Société Internationale de Chirurgie 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4267-e9ee0aeedb505401e865182b69d732d10265e08c7fbbb2f7ff7cdc17d870e4ca3</citedby><cites>FETCH-LOGICAL-c4267-e9ee0aeedb505401e865182b69d732d10265e08c7fbbb2f7ff7cdc17d870e4ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-020-05424-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-020-05424-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32095855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Chetana</creatorcontrib><creatorcontrib>Goumard, Claire</creatorcontrib><creatorcontrib>Casellas-Robert, Margarida</creatorcontrib><creatorcontrib>Lopez-Ben, Santiago</creatorcontrib><creatorcontrib>Lladó, Laura</creatorcontrib><creatorcontrib>Busquets, Juli</creatorcontrib><creatorcontrib>Salloum, Chady</creatorcontrib><creatorcontrib>Albiol-Quer, Maria Teresa</creatorcontrib><creatorcontrib>Castro-Gutiérrez, Ernest</creatorcontrib><creatorcontrib>Rosmorduc, Olivier</creatorcontrib><creatorcontrib>Feray, Cyrille</creatorcontrib><creatorcontrib>Ramos, Emilio</creatorcontrib><creatorcontrib>Figueras, Joan</creatorcontrib><creatorcontrib>Scatton, Olivier</creatorcontrib><creatorcontrib>Azoulay, Daniel</creatorcontrib><title>Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC.
Methods
All initially transplantable HCC patients undergoing hepatectomy with either narrow (<10 mm) or wide (≥10 mm) margins from 2007 to 2016 at four Western university centers were compared in terms of recurrence, transplantability of recurrence, recurrence-free survival (RFS), and intention-to-treat overall survival (ITT-OS). Independent predictors of non-transplantability of recurrence were assessed.
Results
This study included 187 patients (narrow group,
n
= 107 vs. wide group,
n
= 80). Recurrence was significantly more frequent in the narrow margin group (44% vs. 26%;
p
= 0.01) with a shorter RFS (
p
= 0.03). The transplantability of recurrence and ITT-OS were, however, not different between the two groups. The presence of satellite nodules on the resected specimens emerged as the sole independent predictor of non-transplantability of tumor recurrence. The stratification of the analysis according to the presence of cirrhosis achieved essentially the same results as in the whole study population.
Conclusions
Narrow margin was associated with a higher tumor recurrence rate and a shorter RFS for patients with initially transplantable HCC. However, transplantability of recurrence and long-term ITT-OS were not impaired.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiac Surgery</subject><subject>Cirrhosis</subject><subject>Female</subject><subject>General Surgery</subject><subject>Hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Intention to Treat Analysis</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Margins of Excision</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Nodules</subject><subject>Original Scientific Report</subject><subject>Population studies</subject><subject>Salvage Therapy</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcFu1DAQhi0EosvCC3BAlrhwCUzsOMn2tqwoXdRqEbuIY-Q4k60rx97aTqt9ON4NlxSQOCAkS5bG3z__eH5CXubwNgeo3gUAVtYZMMhAFKzI2CMyywvOMsYZf0xmwMtU5Dk_Ic9CuAbIqxLKp-SEM1iIWogZ-b4eDlJF6izdWOWM22slDd2MUbkBA5W2o2sb0cYsumznUUa6Hf2tvk2U6-kXDKiiTvJL6ffa0t55uvPShoORNsrWID3Hg4xOoTGjkZ6upFfaukHShC-NyVbJyU9WqfJZRp3sAr3T8YqutPdXLuhwSpf0cjRRq_SInm7j2B2fkye9NAFfPNxz8vXsw251nl1sPq5Xy4tMFaysMlwggkTsWpEWBTnWpchr1paLruKsy9MaBUKtqr5tW9ZXfV-pTuVVV1eAhZJ8Tt5MfQ_e3YwYYjPocP8hadGNoWFp0VCUPJ05ef0Xeu1Gb9N0iVqIQoiyFIliE6W8C8Fj3xy8HqQ_Njk09-E2U7hNCrf5GW5Sz8mrh9ZjO2D3W_IrzQScTsCdNnj8j5bNt0_b92cARVElMZ_EIensHv2fwf8x0w8By8Ol</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Lim, Chetana</creator><creator>Goumard, Claire</creator><creator>Casellas-Robert, Margarida</creator><creator>Lopez-Ben, Santiago</creator><creator>Lladó, Laura</creator><creator>Busquets, Juli</creator><creator>Salloum, Chady</creator><creator>Albiol-Quer, Maria Teresa</creator><creator>Castro-Gutiérrez, Ernest</creator><creator>Rosmorduc, Olivier</creator><creator>Feray, Cyrille</creator><creator>Ramos, Emilio</creator><creator>Figueras, Joan</creator><creator>Scatton, Olivier</creator><creator>Azoulay, Daniel</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study</title><author>Lim, Chetana ; Goumard, Claire ; Casellas-Robert, Margarida ; Lopez-Ben, Santiago ; Lladó, Laura ; Busquets, Juli ; Salloum, Chady ; Albiol-Quer, Maria Teresa ; Castro-Gutiérrez, Ernest ; Rosmorduc, Olivier ; Feray, Cyrille ; Ramos, Emilio ; Figueras, Joan ; Scatton, Olivier ; Azoulay, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4267-e9ee0aeedb505401e865182b69d732d10265e08c7fbbb2f7ff7cdc17d870e4ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiac Surgery</topic><topic>Cirrhosis</topic><topic>Female</topic><topic>General Surgery</topic><topic>Hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Intention to Treat Analysis</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Margins of Excision</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Nodules</topic><topic>Original Scientific Report</topic><topic>Population studies</topic><topic>Salvage Therapy</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Chetana</creatorcontrib><creatorcontrib>Goumard, Claire</creatorcontrib><creatorcontrib>Casellas-Robert, Margarida</creatorcontrib><creatorcontrib>Lopez-Ben, Santiago</creatorcontrib><creatorcontrib>Lladó, Laura</creatorcontrib><creatorcontrib>Busquets, Juli</creatorcontrib><creatorcontrib>Salloum, Chady</creatorcontrib><creatorcontrib>Albiol-Quer, Maria Teresa</creatorcontrib><creatorcontrib>Castro-Gutiérrez, Ernest</creatorcontrib><creatorcontrib>Rosmorduc, Olivier</creatorcontrib><creatorcontrib>Feray, Cyrille</creatorcontrib><creatorcontrib>Ramos, Emilio</creatorcontrib><creatorcontrib>Figueras, Joan</creatorcontrib><creatorcontrib>Scatton, Olivier</creatorcontrib><creatorcontrib>Azoulay, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Chetana</au><au>Goumard, Claire</au><au>Casellas-Robert, Margarida</au><au>Lopez-Ben, Santiago</au><au>Lladó, Laura</au><au>Busquets, Juli</au><au>Salloum, Chady</au><au>Albiol-Quer, Maria Teresa</au><au>Castro-Gutiérrez, Ernest</au><au>Rosmorduc, Olivier</au><au>Feray, Cyrille</au><au>Ramos, Emilio</au><au>Figueras, Joan</au><au>Scatton, Olivier</au><au>Azoulay, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2020-06</date><risdate>2020</risdate><volume>44</volume><issue>6</issue><spage>1966</spage><epage>1974</epage><pages>1966-1974</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
The outcomes of liver resection (LR) with a narrow margin in patients with transplantable hepatocellular carcinoma (HCC) have not been studied. The aim was to assess whether narrow margin following up-front LR impacts the incidence, timing, pattern, and transplantability of tumor recurrence in patients with initially transplantable HCC.
Methods
All initially transplantable HCC patients undergoing hepatectomy with either narrow (<10 mm) or wide (≥10 mm) margins from 2007 to 2016 at four Western university centers were compared in terms of recurrence, transplantability of recurrence, recurrence-free survival (RFS), and intention-to-treat overall survival (ITT-OS). Independent predictors of non-transplantability of recurrence were assessed.
Results
This study included 187 patients (narrow group,
n
= 107 vs. wide group,
n
= 80). Recurrence was significantly more frequent in the narrow margin group (44% vs. 26%;
p
= 0.01) with a shorter RFS (
p
= 0.03). The transplantability of recurrence and ITT-OS were, however, not different between the two groups. The presence of satellite nodules on the resected specimens emerged as the sole independent predictor of non-transplantability of tumor recurrence. The stratification of the analysis according to the presence of cirrhosis achieved essentially the same results as in the whole study population.
Conclusions
Narrow margin was associated with a higher tumor recurrence rate and a shorter RFS for patients with initially transplantable HCC. However, transplantability of recurrence and long-term ITT-OS were not impaired.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32095855</pmid><doi>10.1007/s00268-020-05424-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2020-06, Vol.44 (6), p.1966-1974 |
| issn | 0364-2313 1432-2323 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals; Access via Wiley Online Library |
| subjects | Abdominal Surgery Aged Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiac Surgery Cirrhosis Female General Surgery Hepatectomy Hepatectomy - methods Hepatocellular carcinoma Humans Intention to Treat Analysis Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Neoplasms - complications Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Male Margins of Excision Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - surgery Nodules Original Scientific Report Population studies Salvage Therapy Surgery Survival Survival Rate Thoracic Surgery Treatment Outcome Tumors Vascular Surgery |
| title | Impact on Oncological Outcomes and Intent-to-Treat Survival of Resection Margin for Transplantable Hepatocellular Carcinoma in All-Comers and in Patients with Cirrhosis: A Multicenter Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A28%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20on%20Oncological%20Outcomes%20and%20Intent-to-Treat%20Survival%20of%20Resection%20Margin%20for%20Transplantable%20Hepatocellular%20Carcinoma%20in%20All-Comers%20and%20in%20Patients%20with%20Cirrhosis:%20A%20Multicenter%20Study&rft.jtitle=World%20journal%20of%20surgery&rft.au=Lim,%20Chetana&rft.date=2020-06&rft.volume=44&rft.issue=6&rft.spage=1966&rft.epage=1974&rft.pages=1966-1974&rft.issn=0364-2313&rft.eissn=1432-2323&rft_id=info:doi/10.1007/s00268-020-05424-2&rft_dat=%3Cproquest_cross%3E2364046346%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2395455665&rft_id=info:pmid/32095855&rfr_iscdi=true |