Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention

The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their polymorphism on the cancer development risk. The carcinogenic activity of different types of drugs, from the anticancer agents to analgesics, antipyr...

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Veröffentlicht in:	Biochemistry (Moscow) 2020, Vol.85 (Suppl 1), p.79-107
Hauptverfasser:	Belitskiy, G. A., Kirsanov, K. I., Lesovaya, E. A., Yakubovskaya, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimitotic agents Antineoplastic agents Antineoplastic Agents - adverse effects Aristolochic Acids - adverse effects Arsenic - adverse effects B cells Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Carcinogenesis Carcinogenesis - chemically induced Carcinogens Development and progression Diethylstilbestrol - adverse effects DNA Damage - drug effects Epidemiology Estrogens - adverse effects Health aspects Humans Immunosuppressive Agents - adverse effects Life Sciences Microbiology Neoplasms - chemically induced Neoplasms - prevention & control Phenacetin - adverse effects Precision Medicine Prevention Review Risk Factors
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Beschreibung
Zusammenfassung:	The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their polymorphism on the cancer development risk. The carcinogenic activity of different types of drugs, from the anticancer agents to analgesics, antipyretics, immunomodulators, hormones, natural remedies, and non-cancer drugs, is described. Possible approaches for the prevention of drug-related cancer induction at the initiation and promotion stages are discussed.
ISSN:	0006-2979 1608-3040
DOI:	10.1134/S0006297920140059