Transfer of ubiquitin protein caught in the act

Transfer of ubiquitin protein caught in the act

A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. Structural data reveal a key step that regulates protein degradatio...

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Veröffentlicht in:Nature (London) 2020-02, Vol.578 (7795), p.372-373
Hauptverfasser: Deshaies, Raymond J., Pierce, Nathan W.
Format: Artikel
Sprache:eng
Schlagworte:
631/535
631/80
Amino acids
Bacterial diseases
Bacterial infections
Cullin Proteins
Enzymes
Genetic aspects
Glutamine
Mutants
News And Views
Proteins
Substrates
Ubiquitin
Ubiquitin-proteasome system
Ubiquitin-protein ligase
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Beschreibung
Zusammenfassung:A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. Structural data reveal a key step that regulates protein degradation.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-020-00325-9