Tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol and its metabolites in pigs after oral exposure

The tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol (8:2 FTOH) were evaluated in pigs after oral exposure of a dose of 5 mg/kg.b.w.d. for 7 d. The bioaccumulation of 8:2 FTOH and its metabolites showed significant differences among the various tissues. The parent compound was qu...

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Veröffentlicht in:Chemosphere (Oxford) 2020-06, Vol.249, p.126016-126016, Article 126016
Hauptverfasser: Xie, Shuyu, Cui, Yonghui, Yang, Yujuan, Meng, Kuiyu, Pan, Yuanhu, Liu, Zhenli, Chen, Dongmei
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Sprache:eng
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Zusammenfassung:The tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol (8:2 FTOH) were evaluated in pigs after oral exposure of a dose of 5 mg/kg.b.w.d. for 7 d. The bioaccumulation of 8:2 FTOH and its metabolites showed significant differences among the various tissues. The parent compound was quickly depleted, and the main metabolites perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), and 3-perfluoroheptyl propanoic acid (7:3 FTCA) were detected in all tissues examined. The relative elimination half-life (T1/2re) calculated by compound concentration of 7:3 FTCA and PFOA was longest in kidney tissue (8.60 and 23.9 d, respectively), while their absolute elimination half-life (T1/2ab) of 7:3 FTCA and PFOA calculated by compound amount was longest in kidney tissue (10.41 and 64.1 d, respectively). The T1/2re and T1/2ab for PFHpA was longest in heart tissue (19.3 d and 30.26 d, respectively).The accumulated PFOA in kidney and liver tissues was still above the detection limit (LOD) at 21 d postdosing. These results indicate that PFOA and the kidneys are the ideal biomonitoring marker and target tissue, respectively, for 8:2 FTOH pollution. The T1/2 values of the main metabolites were of long duration compared to the growth cycle of farmed pigs (approximately 180 d) before slaughter; therefore, pigs contaminated with 8:2 FTOH present a potential risk to humans. [Display omitted] •The LC-MS/MS method was used for detecting 8:2 FTOH and its metabolites.•8:2 FTOH was quickly depleted in porcine tissues.•8:2 FTOH and its metabolites were selectively accumulated in different tissues.•PFHpA, PFOA, and 7:3 FTCA with a carboxy group exhibited strong bioaccumulation.•PFOA and kidney are the potential biomonitoring marker and tissue, respectively, for 8:2 FTOH.
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2020.126016