Careful consideration of hypotheses and model assumptions in study of non-specific effects of vaccines

Careful consideration of hypotheses and model assumptions in study of non-specific effects of vaccines

[...]a major assumption of the SCCS method is that exposure should not depend on events [2]. [...]age is a major time-varying confounder as recognized by the authors [1]. Randomized trials of already recommended vaccines are often not ethically possible. [...]we largely have to rely on observational...

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Veröffentlicht in:Vaccine 2020-02, Vol.38 (9), p.2115-2115
1. Verfasser: Sørup, Signe
Format: Artikel
Sprache:eng
Schlagworte:
Age
Immunization
Infections
Observational studies
Vaccines
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:[...]a major assumption of the SCCS method is that exposure should not depend on events [2]. [...]age is a major time-varying confounder as recognized by the authors [1]. Randomized trials of already recommended vaccines are often not ethically possible. [...]we largely have to rely on observational studies of non-specific effects of vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2020.01.011