Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes

To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achie...

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Veröffentlicht in:	Diabetes care 2020-04, Vol.43 (4), p.813-820
Hauptverfasser:	Zhyzhneuskaya, Sviatlana V, Al-Mrabeh, Ahmad, Peters, Carl, Barnes, Alison, Aribisala, Benjamin, Hollingsworth, Kieren G, McConnachie, Alex, Sattar, Naveed, Lean, Michael E J, Taylor, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antidiabetics Arginine Beta cells Chemotherapy Clinical trials Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Diet Female Humans Hyperglycemia Insulin Insulin - blood Insulin secretion Insulin Secretion - physiology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Male Middle Aged Recovery of Function Reference Values Remission Remission (Medicine) Remission Induction Research design Secretion Time Factors Treatment Outcome Weight loss Weight Loss - physiology Weight Reduction Programs Young Adult
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Zusammenfassung:	To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achieved remission (HbA
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc19-0371