Nucleus-targeting ultrasmall ruthenium() oxide nanoparticles for photoacoustic imaging and low-temperature photothermal therapy in the NIR-II window

Nucleus-targeting NPs based on RuO 2 ( RuO 2 NPs ) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO 2 NPs with good biocompatibility and excellent photothermal properties but also their unique potential for the nucleus-targeted low-temperature PTT. In the present study novel ultrasmall CS-RuO 2 NPs with intrinsic nuclear-targeting properties were developed for photoacoustic imaging and low-temperature photothermal therapy of cancer in the NIR-II window.