Activated PI3K/AKT Signaling Pathway Associates with Oxidative Stress and Impaired Developmental Potential of Vitrified-Thawed Oocytes

It was suggested that the compromised developmental potential of vitrified-thawed oocytes was due to the oxidative stress occurred during the process. PI3K/AKT signaling pathway is important in response to stress. The present study aimed to investigate the role of PI3K/AKT played in oocyte vitrifica...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2020, Vol.27 (1), p.404-410
Hauptverfasser:	Li, Jun, Yang, Xuemei, Liu, Fang, Song, Yaman, Liu, Yuanke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cryopreservation Embryology Female Fertilization in Vitro - methods Medicine Medicine & Public Health Membrane Potential, Mitochondrial - physiology Mice Obstetrics/Perinatology/Midwifery Oocytes - metabolism Oogenesis - physiology Original Article Oxidative Stress - physiology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Reproductive Medicine Signal Transduction - physiology Vitrification
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Zusammenfassung:	It was suggested that the compromised developmental potential of vitrified-thawed oocytes was due to the oxidative stress occurred during the process. PI3K/AKT signaling pathway is important in response to stress. The present study aimed to investigate the role of PI3K/AKT played in oocyte vitrification and thawing. The results revealed that the fertilization rate, cleavage rate, as well as the blastocyst formation rate were significantly lower in the vitrified-thawed oocytes than that of the control counterparts [63.81 ± 7.19 vs. 82.00 ± 4.21% ( P
ISSN:	1933-7191 1933-7205
DOI:	10.1007/s43032-019-00036-1