Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of Chroman-4-ones and Dihydroquinolin-4-ones

Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of Chroman-4-ones and Dihydroquinolin-4-ones

A novel visible-light photoredox catalysis protocol for the effective and efficient synthesis of 3-substituted chroman-4-ones and 2,3-dihydroquinolin-4­(1H)-ones via tandem radical addition/cyclization of alkenyl aldehydes has been described. This reaction features a broad substrate scope, mild reac...

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Veröffentlicht in:Journal of organic chemistry 2020-03, Vol.85 (5), p.3963-3972
Hauptverfasser: Huang, Hong-Li, Du, Ji-Yuan, Li, Qian-Li, Gao, Fei, Ma, Chun-Lin
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel visible-light photoredox catalysis protocol for the effective and efficient synthesis of 3-substituted chroman-4-ones and 2,3-dihydroquinolin-4­(1H)-ones via tandem radical addition/cyclization of alkenyl aldehydes has been described. This reaction features a broad substrate scope, mild reaction conditions, and good functional group tolerance character.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b03253