Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of ()-1,2-diols from racemic epoxides

Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design. The elegant one-step enantioconvergent hydrolysis of seven rac -epoxides was achieved by single mutants, allowing green and efficient...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (18), p.2799-282
Hauptverfasser:	Hu, Die, Zong, Xun-Cheng, Xue, Feng, Li, Chuang, Hu, Bo-Chun, Wu, Min-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Alcohols - metabolism Diols Epoxide Hydrolases - chemistry Epoxide Hydrolases - metabolism Epoxy Compounds - chemistry Epoxy Compounds - metabolism French beans Models, Molecular Molecular Conformation Phaseolus - enzymology Regioselectivity Stereoisomerism Substrates
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